Madhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 3
Abstract
Objective: Present study was designed to screen the antiepileptic property of aqueous extract of Madhucalongifolia (AqML) in laboratory animals. Materials and methods: Rat and mice were divided in different groups. Antiepileptic activity was tested by using maximal electric shock (MES), Pentylenetertrazole (PTZ) and lithium pilocarpine (Li-Pilocarpine) models. Treatment group of animals were received AqML at 100, 200 and 400 mg/kg p.o. for 7 days. At the end of treatment period, different parameters related of antiepileptic action were observed. Result: Preliminary phytochemical investigation revealed the presence of carbohydrate, protein, amino acid and alkaloids. Animals treatment with AqML showed significant (p<0.05) antiepileptic activity in MES, PTZ and li-pilocarpine screening models. In all the screening models AqML showed dose dependant prevention in seizure was observed and of them dose 400mg/kg p.o. was found to be very significant (p<0.05) antiepileptic effect. Conclusion: The result revealed that AqML at 400 mg/kg p.o. possesses antiepileptic activity in MES, PTZ and Li-pilocarpine models.
Authors and Affiliations
Chandrakant V Thakare, Chandrashekhar D Upasani
Keywords
Related Articles
- EP ID EP589766
- DOI -
- Views 59
- Downloads 0
Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats
Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containing...
Anti cancer activity of Trachyspermum ammi against MCF-7 cell lines mediates by p53 and Bcl-2 mRNA levels
Breast cancer is second most common in women and accounts for 23% of all occurring cancers in women. Patients with breast cancer have increasingly shown resistance and high toxicity to chemotherapeutic drugs. Plant-deriv...
Standardization of Vyoshadi Saktu a Pathykalpana (Nutritional supplement) in Diabetes
Neuropathy and Cardiac complications are the most common trouble in diabetes mellitus with progressive damage due to complex pathogenesis. Many conventional pharmacological agents were withdrawn from clinical studies eit...
Cytotoxicological evaluation of semi-purified extracts of some dye yielding plants of the Kashmir Valley on Normal Intestinal Cell Line (IEC-6) by MTT assay
Plant extracts are widely used in many fields and there is a need to evaluate their cytotoxic effect to determine their non-cytotoxic concentration at which they can be used in a safe manner. Keeping this in view, the pr...
Hepatic tolerance of an ethyl acetate extract of Holarrhena floribunda (G. Don) Durand and Schinz leaves in Wistar Rats
Purpose: This study aims to evaluate the hepatic biochemical effects associated with the use of ethyl acetate extract of Holarrhena floribunda leaves as a traditional medicine. Methods: The rats were randomly divided int...