Madhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 3
Abstract
Objective: Present study was designed to screen the antiepileptic property of aqueous extract of Madhucalongifolia (AqML) in laboratory animals. Materials and methods: Rat and mice were divided in different groups. Antiepileptic activity was tested by using maximal electric shock (MES), Pentylenetertrazole (PTZ) and lithium pilocarpine (Li-Pilocarpine) models. Treatment group of animals were received AqML at 100, 200 and 400 mg/kg p.o. for 7 days. At the end of treatment period, different parameters related of antiepileptic action were observed. Result: Preliminary phytochemical investigation revealed the presence of carbohydrate, protein, amino acid and alkaloids. Animals treatment with AqML showed significant (p<0.05) antiepileptic activity in MES, PTZ and li-pilocarpine screening models. In all the screening models AqML showed dose dependant prevention in seizure was observed and of them dose 400mg/kg p.o. was found to be very significant (p<0.05) antiepileptic effect. Conclusion: The result revealed that AqML at 400 mg/kg p.o. possesses antiepileptic activity in MES, PTZ and Li-pilocarpine models.
Authors and Affiliations
Chandrakant V Thakare, Chandrashekhar D Upasani
Keywords
Related Articles
- EP ID EP589766
- DOI -
- Views 65
- Downloads 0
Antioxidant and anticancer activities of an Aporphine alkaloid isolated from Alphonsea sclerocarpa
Herein, we report on the anticancer and antioxidant activity of an Aporphine alkaloid isolated from medicinal plant Alphonsea sclerocarpa. Conventional column chromatography and preparative HPLC methods were used to isol...
Ethnomedicinal survey of plants used by tribal in Lalgarh forest range, W.B., India
Exploration of the traditional knowledge of the indigenous people is very important for revealing the uses of plants and plant parts for medicinal purpose. Once the medicinal use of these plants is known, their active in...
Experimental study of the effectiveness the Capsicum annuum L. extracts for treatment of the rheumatoid arthritis
The treatment of rheumatoid arthritis with the use of alcohol extracts of Capsicum annuum L. is widely practiced in traditional medicine on the territory of southern Ukraine. The purpose of this study was the experimenta...
Bioefficacy of Selected Plant Extracts against Sitophilus zeamais on Post-Harvest Management of Zea mays
Maize (Zea mays L.) is the most important cereal crop in Kenya with 90% of the total population relying on it as the main staple food. Post-harvest loss in maize is caused by insect pests such Sitophilus zeamais and Larg...
Understanding the role of quercetin during neurotoxicity induced by Chlorpyrifos
Organophosphate Chlorpyrifos (CPF), a pesticide, is widely used across the world to control worms and insects. It is highly toxic and causes neurobehavioral disorders. Naturally occurring compounds having polyphenols as...