Magnesium content in pancreatic islets, thymus and blood lymphocytes in animals under conditions of diabetes and stress modeling
Journal Title: Екологічні науки - Year 2018, Vol 21, Issue
Abstract
In experiments on mice and rats with diabetes, stress was studied on the content of magnesium – a macro element that increases the body’s protective properties, blood lymphocytes, cells of the pancreas and thymus glands of animals. Experimental diabetes in animals was induced by subcutaneous administration of aloxane, and for stress modeling, they injected adrenaline and prednisolone. For cytochemical detection of magnesium in pancreatic β cells, thymic epithelial cells (TEС) and blood lymphocytes of experimental animals, methods developed in our laboratory were used. The accumulation of magnesium in the β-cells of pancreatic islets, thymus cells and blood lymphocytes is established when adrenaline and prednisolone are administered to mice and rats whose elevation in the blood accompanies the development of acute stress reaction characterized by activation of the sympathetic part of the nervous system and adrenal function. After injections of adrenal hormones with aloxane diabetes, partial correction of magnesium deficiency in the studied cells was observed. The positive correlation of changes in the amount of metal in the studied cells of animals indicates the existence of close immune-insular relationships.
Authors and Affiliations
Н. В. Григорова
Keywords
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