Malhotra
Journal Title: International Journal of Medical Science and Public Health - Year 2018, Vol 7, Issue 11
Abstract
Background: Meningitis is a common clinical problem, caused by various bacteria and viruses. Its etiology needs to be ascertained swiftly to institute appropriate therapy to prevent morbidity and mortality. In some cases, the precise etiological diagnosis cannot be ascertained in spite of thorough work up. Objectives: The present study was a prospective study undertaken in cases of meningitis admitted in the Medicine Ward of Burdwan Medical College and Hospital to determine the levels of cerebrospinal fluid (CSF) lactate dehydrogenase (LDH), and creatine phosphokinase (CPK) concentration and their possible roles in the etiological diagnosis of different kinds of meningitis. Materials and Methods: A prospective study was conducted on 150 patients, 50 patients of each of bacterial, viral, and tubercular meningitis, admitted in the Medicine Ward of Burdwan Medical College and Hospital. The values of CSF CPK, and LDH were calculated for each patient and variation of means was analyzed by appropriate biomedical software. The SPSS for the Windows 20.0 statistical package program has been used in the evaluation of the data. The quantitative data of the groups were compared using ANOVA with post hoc test for comparison. P < 0.05 was considered statistically significant. Results: It was found that CSF LDH, and CPK were significantly elevated in pyogenic meningitis and tubercular meningitis as compared to viral meningitis. The differences between the CSF LDH, and CSF-CPK values in differentiating any one of the three forms against another were found to be statistically significant. Conclusion: Thus, CSF CPK and LDH may serve as an useful marker for differentiation of etiology of meningitis at least in conjunction with the classical CSF markers and especially in the doubtful cases.
Authors and Affiliations
Ankur Banik, Sourish Chatterjee, Milan Chakraborty
Keywords
Related Articles
- EP ID EP489561
- DOI 10.5455/ijmsph.2018.0721124072018
- Views 86
- Downloads 0
Level of serum prolactin in patients of hypothyroidism in Western Uttar Pradesh
Background: Hypothyroidism refers to a state that results in a deficiency of thyroid hormones, including hypothalamic or pituitary disease and generalized tissue resistant to thyroid hormone. Thyroid-releasing hormone ca...
Evaluation of changes in retinal fiber layer thickness in pseudoexfoliation syndrome using spectral domain optical coherence tomography
Background: Pseudoexfoliation syndrome (PEX) is a disorder characterized by the progressive accumulation of fibrillary extracellular deposits in several ocular tissues including the iris, anterior chamber angle, lens cap...
Malnutrition among under-five tribal children with special focus on dietary intake in Akole block of Western Ghat, Maharashtra, India
Background: Malnutrition is a global issue that affects billions. The social and economic backwardness has always been responsible for poor health status, high incidence of low birth weight, and infant and child mortalit...
Awareness and safety practices regarding occupational hazards of dyestuff industrial workers of Vatva industries, Ahmedabad
Background: Dyestuff industries have growing market in India. India’s dye industry produces every type of dyes and pigments and production of dyestuff and pigments in India is close to 80,000 tones. Objectives: (1) To as...
Insomnia and its associated factors: A cross-sectional study in rural adults of North India
Background: Insomnia is one of the common but most neglected issues which may have many serious long-term illhealth effects, thus affecting quality of life. Its incidence is showing an upward trend in ever-increasing pre...