Malignant infantile osteopetrosis, presenting as hemolytic anemia: a case report
Journal Title: International Journal of Medical Science and Public Health - Year 2016, Vol 5, Issue 1
Abstract
The occurrence of malignant infantile osteopetrosis is observed in early stages of life along with increased sclero - sis of the skeleton and decreased bone marrow spaces. The bone marrow damage of the disease leads to anemia, extramedullary hematopoiesis secondary to anemia, which result in hepatosplenomegaly, cranial nerves compres - sion (optic nerve atrophy), and severe growth failure. The characteristic symptoms of the disease are fractures, visual damage, and bone marrow failure resulting in severe anemia. A 4-month-old infant presented with severe anemia and hepatosplenomegaly, bilateral optic atrophy, and acute respiratory tract infection. It was first thought to be hemolytic anemia or intrauterine infection. Radiological features, bone marrow studies, and clinical progression clinched the diag - nosis of malignant infantile osteopetrosis. As it is a rare cause of severe anemia, clinicians should have sufficient idea about it.
Authors and Affiliations
Shubhankar Mishra, Sunil Kumar Agarwalla, Bikash Ranjan Praharaj, Sushant Kumar Behera
Keywords
Related Articles
- EP ID EP148932
- DOI 10.5455/ijmsph.2016.260520156
- Views 76
- Downloads 0
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