Mammography Correlated with Histopathology in the Diagnosis of Mass Lesions of the Breast in a Tertiary Teaching Hospital: An Analytical Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Tumors of the breast are characterized by uncontrolled growth of cells in the mammary epithelial tissue. The most frequent type of tumor occurring in females is breast tumors worldwide. Mammography computer-aided digital technique has helped in the diagnosis of early benign and malignant lesions of breast since the beginning of the 21st century. However, false positives are a major concern in breast tumor screening. They are not evaluated as a prognostic factor for tumor detection. Aim: To evaluate the association of false positive results of mammography confirmed with fine needle aspiration cytology (FNAC), histopathological (HPE) features and repeat mammography over a period of 4 years. Study Design: This is a retrospective comparative analytical study. Study Period: June 2012-May 2016 (4 years). Materials and Methods: Results of 2196 patients who underwent mammography in a tertiary teaching hospital, Kerala were included in the study. Demographic details of the sample were obtained from the medical records of the patients. False positive, results were identified based on negative FNAC and HPE findings. Subsequent mammography results of patients of such false positive patients were done to find the incidence of tumor risk. Results: The total number of women patients attending the daily OPDs of the hospital was 6, 70,440 for 4 years. The prevalence of women reporting breast related complaints and undergoing mammography was 0.32%. There was a positive family history of malignant tumors of breast in 14 of the 54 patients (25.92%) confirmed with malignant tumors in this study. Among the 2196 mammography procedures, 1479 were reported as normal (67.34%). Benign lesions of the breast such as cysts, hematoma, localized abscesses, galactocele, and fibroadenosis were reported in 389 women (17.71%). 274 women had shown benign tumors of breast reported following mammography (12.47%) such as fibroma, neurofibroma, fibroadenoma, and simple adenoma. The remaining 54 mammography results were showing features of a malignant tumor on mammography were subjected to dynamic contrast enhanced magnetic resonance imaging (DCEMRI), and diffusion-weighted images (DWI) of the breast. Conclusion: Mammography screening proves to be an excellent tool in the diagnosis of diseases of the breast. There is a definite relation between the presence of a false positive test and the risk of cancer detection in subsequent screening participations. The association was much clear in false positives involving a cytology examination or biopsy, and in women with a family history of breast cancer.
Authors and Affiliations
Sheethal Shanibi, C K Rajamma
Keywords
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