Management and outcome of hepatitis B reactivation in immunocompromised patients
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 1
Abstract
INTRODUCTION: Hepatitis B virus reactivation(HBVR) is known to occur in cancer patients receiving chemotherapy. HBVR has high rate of mortality even after treatment. MATERIAL AND METHODS: This prospective study was conducted from October 2012 to January 2015. All adult malignancy patients with evidence of HBVR were included in the study. Patients with co-infection with other hepatitis viruses or HIV and HCC were excluded. Patients were randomized to receive either entecavir or tenofovir. Efficacy of two drugs was compared by assessing the reduction in HBV DNA level at 6 months and the proportion of patients with undetectable HBV DNA and HBsAg loss at 48 weeks. RESULTS: 92 patients of HBVR were seen, 46 received entecavir and 46 received tenofovir. HBV DNA level decreased from a mean of 7.749(±1.19) log IU/ml at baseline to 3.175(±0.89) log IU/ml at 6 months in entecavir group with reduction of 4.7 logs where as HBV DNA level decreased from a mean of 7.879(±1.08) log IU/ml at baseline to 2.655(±0.58) log IU/ml in tenofovir group with reduction of 5.224 logs(p= 0.029). At 1 year, 35.1% had undetectable DNA and 40.5% had HBsAg loss in entecavir group whereas 46.9% had undetectable DNA and 40.6% had HBsAg loss in tenofovir group(p=0.32 & 0.99). No HBVR related death was seen in any group. CONCLUSION: Both entecavir and tenofovir are very effective and equally effective in the treatment of HBVR in cancer patients.
Authors and Affiliations
Manzoor Ahmad Wani, Jaswinder Singh Sodhi, Sheikh Aejaz Aziz, Sajad Geelani, Showkat Ali Zargar, Imtiyaz Wani
Keywords
Related Articles
- EP ID EP436354
- DOI -
- Views 55
- Downloads 0
Limited intimal tear
Limited intimal tears of the aorta presenting as acute aortic syndrome are notoriously difficult to diagnose prospectively, reported to elude all cross-sectional imaging techniques. Although this entity has been included...
SPRINT: More Intensive Blood Pressure Management Saves Lives
A more intensive strategy of blood pressure management reduces the risk for death and cardiovascular events when compared with a strategy that lowers systolic blood pressure to the conventional target of 140 mm Hg, a lar...
BIOMARKERS OF SEPSIS
Sepsis is a state caused by microbial invasion from a local infectious source into the blood stream which leads to signs of systemic illness in remote organs,” this was the first scientific definition of sepsis proposed...
Splenic Lymphangioma: A Rare Tumour of Spleen in Adults
Splenic Lymphangioma is a rare, benign, cystic lesion arising from malformations of splenic lymphatic channels. They are usually found in paediatric population and rarely in adults. Isolated lesions are asymptomatic and...
Comparison of Pregnancy Outcome in Non-Risk and High-Risk Antenatal Mothers
Objectives: 1. To know the incidence of high risk pregnancy. 2. To study the pregnancy outcome in Non-risk and High-risk antenatal mothers. Study Design: Longitudinal study. Setting: Shindolli Village of Belgaum Dist...