Management and outcome of hepatitis B reactivation in immunocompromised patients
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 1
Abstract
INTRODUCTION: Hepatitis B virus reactivation(HBVR) is known to occur in cancer patients receiving chemotherapy. HBVR has high rate of mortality even after treatment. MATERIAL AND METHODS: This prospective study was conducted from October 2012 to January 2015. All adult malignancy patients with evidence of HBVR were included in the study. Patients with co-infection with other hepatitis viruses or HIV and HCC were excluded. Patients were randomized to receive either entecavir or tenofovir. Efficacy of two drugs was compared by assessing the reduction in HBV DNA level at 6 months and the proportion of patients with undetectable HBV DNA and HBsAg loss at 48 weeks. RESULTS: 92 patients of HBVR were seen, 46 received entecavir and 46 received tenofovir. HBV DNA level decreased from a mean of 7.749(±1.19) log IU/ml at baseline to 3.175(±0.89) log IU/ml at 6 months in entecavir group with reduction of 4.7 logs where as HBV DNA level decreased from a mean of 7.879(±1.08) log IU/ml at baseline to 2.655(±0.58) log IU/ml in tenofovir group with reduction of 5.224 logs(p= 0.029). At 1 year, 35.1% had undetectable DNA and 40.5% had HBsAg loss in entecavir group whereas 46.9% had undetectable DNA and 40.6% had HBsAg loss in tenofovir group(p=0.32 & 0.99). No HBVR related death was seen in any group. CONCLUSION: Both entecavir and tenofovir are very effective and equally effective in the treatment of HBVR in cancer patients.
Authors and Affiliations
Manzoor Ahmad Wani, Jaswinder Singh Sodhi, Sheikh Aejaz Aziz, Sajad Geelani, Showkat Ali Zargar, Imtiyaz Wani
Keywords
Related Articles
- EP ID EP436354
- DOI -
- Views 52
- Downloads 0
Spinal Anaesthesia for Infra-umbilical Surgeries - A Prospective Randomized Study to evaluate the effectiveness of Dexmedetomidine as an adjuvant to Bupivacaine.
Background: Spinal anesthesia is commonly used anesthetic modality worldwide but with the limitation of relatively short duration of action and complain of post-operative pain. However, the addition of adjuvants have int...
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Sepsis, a syndrome of physiologic, pathologic, and biochemical abnormalities induced by infection, is a major public health concern, accounting for more than $20 billion (5.2%) of total US hospital costs in 2011.The repo...
Hepatitis in Developing Countries: Still a Scourge
Screening is defined as the application of a diagnostic test to an asymptomatic population in order to detect a disease at a stage when intervention may improve its outcome and natural history.1 In simpler terms, screeni...
Pulmonary Tuberculosis Presenting As Total Lung Consolidation and Acute Respiratory Failure An Unusual Presentation
Tuberculosis has varied clinical and radiological presentations, ranging from constitutional symptoms with segmental involvement to severe forms with multiple lobar consolidation and high mortality. Though uncommon, resp...
Collection and Transport of Blood
Blood cultures are collected from patients with suspected sepsis or bacteremia and are essential in the diagnosis and treatment of the etiologic agent of septicemia.