Management and Prognostic factors of survival liposarcoma of the limbs: A retrospective study of 50 patients.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Background: The purpose of our study was to analyze epidemiological, clinical and therapeutic data to determine histoprognostic risk factors associated with overall survival (OS) and progression free survival (PFS) in the liposarcoma (LS) of the limbs. Methods: This was a retrospective study of 50 cases ofLS of the limbs treated at the Salah Azaiz institute from 1995 to 2015. We analyzed the clinical, pathological features and outcome of our patients. Results: By the histological subtype, 5 years OS was 82% in well differentiated, 61% in myxoid, 50% in mixed and 0% in pleomorphic and dedifferentiated (p=0.002). The 5 years OS was 81% and 60% for grade 1, and 10% for grade 3 (p<0.001). Radiotherapy increased the OS from 40% to 70% at 5 years and from 29% to 43 at 10 years (p=0.063). The 2 and 5 years DFS were 36% and 19%, respectively. The one year DFS was 35% for patients with tumors ≤10cm and 0% for tumors >10cm (p=0.013). The one year DFS was 36% for pleomorphic and 0% for myxoid and dedifferentiated (p=0.005). The high grade decreased significantly the 2 years DFS from 37% in case of grade1 to 0% for the grade 3 (p<0.001). Involved surgical margins decreased the one year DFS from 10% to 0% (p<0.001). High grade (p=0.036) and involved margins (p=0.005)werethe independent predictive factors of metastases. Conclusions: Complete surgical resection remains the only curative treatment of LS, radiotherapy and chemotherapy could be useful especially for prevention and treatment of the relapses.
Authors and Affiliations
Ines Ben Safta, Mouna Ayadi, Houyem Mansouri, Mariem Ladab, Khedija Meddeb, Amina Mokrani, Yosra Yahyaoui, Azza Gabsi, Nesrine Chraiet, Henda Rais, Amel Mezlini
Keywords
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- EP ID EP402363
- DOI 10.9790/0853-1710076872.
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