Management and Prognostic factors of survival liposarcoma of the limbs: A retrospective study of 50 patients.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Background: The purpose of our study was to analyze epidemiological, clinical and therapeutic data to determine histoprognostic risk factors associated with overall survival (OS) and progression free survival (PFS) in the liposarcoma (LS) of the limbs. Methods: This was a retrospective study of 50 cases ofLS of the limbs treated at the Salah Azaiz institute from 1995 to 2015. We analyzed the clinical, pathological features and outcome of our patients. Results: By the histological subtype, 5 years OS was 82% in well differentiated, 61% in myxoid, 50% in mixed and 0% in pleomorphic and dedifferentiated (p=0.002). The 5 years OS was 81% and 60% for grade 1, and 10% for grade 3 (p<0.001). Radiotherapy increased the OS from 40% to 70% at 5 years and from 29% to 43 at 10 years (p=0.063). The 2 and 5 years DFS were 36% and 19%, respectively. The one year DFS was 35% for patients with tumors ≤10cm and 0% for tumors >10cm (p=0.013). The one year DFS was 36% for pleomorphic and 0% for myxoid and dedifferentiated (p=0.005). The high grade decreased significantly the 2 years DFS from 37% in case of grade1 to 0% for the grade 3 (p<0.001). Involved surgical margins decreased the one year DFS from 10% to 0% (p<0.001). High grade (p=0.036) and involved margins (p=0.005)werethe independent predictive factors of metastases. Conclusions: Complete surgical resection remains the only curative treatment of LS, radiotherapy and chemotherapy could be useful especially for prevention and treatment of the relapses.
Authors and Affiliations
Ines Ben Safta, Mouna Ayadi, Houyem Mansouri, Mariem Ladab, Khedija Meddeb, Amina Mokrani, Yosra Yahyaoui, Azza Gabsi, Nesrine Chraiet, Henda Rais, Amel Mezlini
Keywords
Related Articles
- EP ID EP402363
- DOI 10.9790/0853-1710076872.
- Views 29
- Downloads 0
Self Ligating Brackets From Past to Present: An Update
With the consistently advancing orthodontic practices, the idea of self-ligation is promptly acknowledged by clinicians over the globe. Before long, stainless steel and elastomeric ligatures will turn into an obsolete cl...
Oral rehabilitation of patient with access-post retained overdenture denture.
Loss of teeth at any age, either due to periodontal or endodontic problems may cause imbalance in stomatognathic system leading to occlusal disharmony, impaired function and esthetic disfigurement. Therefore, modern dent...
Fxofenadine: Prophylactic Treatment in Allergic Rhinitis
Summary: Allergic rhinitis is commonly found in Kashmir. Prophylactic Fexofenadine shows more promising activity with mild side effects at proper dosage schedule. 10 cases of Allergic Rhinitis were studied during a perio...
A Study on Estimated Glomerular Filtration Rate As A Predictor of Renal Dysfunction Among Adult Hiv Patients on Highly Active Antiretroviral Therapy
Intoduction: Renal dysfunction is the common complication of HIV infection with a prevalence of 30 % in HIV patients. The spectrum of renal dysfunction is multifactorial ranging from exacerbation of chronic kidney diseas...
Management of Maxillary Dento Alveolar Fracture with A Modified Splinting Method :A Case Report
Abstract: The purpose of this case report is to describe the management of a trauma-induced maxillary dentoalveolar fracture in a 7-year-old girl by a modified approach of splinting. The child presented with swelling of...