Management of oral submucous fibrosis by combined oral medication and intralesional injection: A treatment strategy
Journal Title: Medpulse International Journal of Dentistry - Year 2018, Vol 7, Issue 1
Abstract
Background: Oral submucous fibrosis (OSMF) is often described as a condition which is easy to diagnose, but difficult to manage. It is a chronic, debilitating disease of the oral cavity. Though it has a global distribution, it is predominantly a disease of the Indian subcontinent and South East Asia. A standard treatment to manage this condition is not yet available. This article aims at enumerating one of the various treatment modalities of OSMF. Materials and Methods: A total of 30 patients diagnosed with OSMF were treated in Koppal Institute of Medical Sciences for a time period of 9 months, by obtaining the patient’s consent and with the approval of the institution’s research ethical committee. They were treated by administering an intralesional injection of placentrex 1.5ml, dexamethasone1.5 ml, hyaluronidase 1500 IU with 0.5 ml lignocaine HCL injected intralesionally biweekly for 4 weeks along with tablet composition ‘Lycopene, Betacarotene, Selenium, Zinc Sulphate, Copper, Alpha Lipoic Acid’ twice a day followed by mouth opening exercises regularly. Results: Patient’s mouth opening improved for about 7 ± 2 mm (93%), the range being 5-9 mm. Patients had reduced symptoms such as burning sensation, painful ulceration and blanching of oral mucosa. Conclusion: Injection of placentrex, hyaluronidase with dexamethasone combined with oral tablet composition ‘Lycopene, Betacarotene, Selenium, ZincSulphate, Copper, Alpha Lipoic Acid’ is an effective method of managing early stage of OSMF.
Authors and Affiliations
Shrinivas 1, Shushma G, Ramalingeshwara Kantly
Keywords
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