Management of uterine leiomyoma with mifepristone and its outcome in South Indian population
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction Uterine Fibroids are common growth of female reproductive tract in women of reproductive age group So this prospective observational study was conducted to evaluate the effect of low dose Mifepristone treatment for 6 months on the outcome of fibroid size and related symptomMaterials and Methods The study was a prospective observational study conducted at Tertiary care Hospital Tamil Nadu during the period of July 2016 to June 2017 Forty five patients with symptomatic fibroid aged between 2445 years were recruited for the study Baseline data regarding fibroid volume Hb value PBAC Pictorial Blood Assessment Chart VAS Visual analogue Scheme score were recorded The followup data regarding above parameters again collected at the end of 6 months of therapy All patients received 25mg mifepristone daily and comparison was made between pre and post treatment symptoms and leiomyoma volumeResults After therapy with Mifepristone there was a significant reduction in mean volume of fibroid menorrhagia and pain related symptoms The mean leiomyoma volume was reduced from 1043mm3 to 568 mm3 by the end of 6 months of mifepristone therapy Similarly at the end of six months of therapy mean hemoglobin value was also raised by 28gmdl from the baseline mean value of 79gmdl There were no major side effects observed during the course of the study and the drug was well toleratedConclusion Mifepristone is effective against low size uterine leiomyoma and can decrease its associated symptoms among women with symptomatic fibroidsKeywords Mifepristone Leiomyoma Clinical treatment Menorrhagia Dysmenorrhea Uterine fibroid Volume of fibroid Leiomyoma
Authors and Affiliations
Ilangovan Subashree, Geetha Prasad
Keywords
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- EP ID EP475143
- DOI 10.18231/2394-2754.2018.0088
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