Manganese-Enhanced MRI: An Exceptional Tool in Translational Neuroimaging
Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4
Abstract
The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.
Authors and Affiliations
Afonso C. Silva, Nicholas A. Bock
Keywords
Related Articles
- EP ID EP683283
- DOI 10.1093/schbul/sbn056
- Views 110
- Downloads 0
Implementation Considerations for Multisite Clinical Trials with Cognitive Neuroscience Tasks
Multisite clinical trials aimed at cognitive enhancement across various neuropsychiatric conditions have employed standard neuropsychological tests as outcome measures. While these tests have enjoyed wide clinical use an...
Implications of Clinical Trial Design on Sample Size Requirements
The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison group...
Social Cognition in Schizophrenia
Social cognition in schizophrenia is a rapidly emerging area of study. Because the number and diversity of studies in this area have increased, efforts have been made to better define terms and provide organizing framewo...
Psychosis Endophenotypes in Schizophrenia and Bipolar Disorder
Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar...
An Investigation of the Relationship Between Activation of a Social Cognitive Neural Network and Social Functioning
Previous work examining the neurobiological substrates of social cognition in healthy individuals has reported modulation of a social cognitive network such that increased activation of the amygdala, fusiform gyrus, and...