Manganese-Enhanced MRI: An Exceptional Tool in Translational Neuroimaging
Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4
Abstract
The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.
Authors and Affiliations
Afonso C. Silva, Nicholas A. Bock
Keywords
Related Articles
- EP ID EP683283
- DOI 10.1093/schbul/sbn056
- Views 107
- Downloads 0
Psychosis Endophenotypes in Schizophrenia and Bipolar Disorder
Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar...
Imitation, Simulation, and Schizophrenia
The social significance of imitation is that it provides internal tools for understanding the actions of others by simulating or forming internal representations of these actions. Imitation plays a central role in human...
Current Psychopathological Issues in Psychosis: Towards a Phenome-wide Scanning Approach
Supported in part by a grant of the Health Department of the Navarre Government, Spain (55/2007).
Studying and Treating Schizophrenia Using Virtual Reality: A New Paradigm
Understanding schizophrenia requires consideration of patients’ interactions in the social world. Misinterpretation of other peoples’ behavior is a key feature of persecutory ideation. The occur...
Building a Clinically Relevant Cognitive Task: Case Study of the AX Paradigm
Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processin...