Manganese-Enhanced MRI: An Exceptional Tool in Translational Neuroimaging
Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4
Abstract
The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.
Authors and Affiliations
Afonso C. Silva, Nicholas A. Bock
Keywords
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- EP ID EP683283
- DOI 10.1093/schbul/sbn056
- Views 92
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