Mannitol Vs Hypertonic Saline in the Treatment of Increased Intracranial Pressure in Traumatic Brain Injury Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Medical management of increased intracranial pressure should include sedation, drainage of cerebrospinal fluid, and osmotherapy with either mannitol or hypertonic saline. The aim of this study is to compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HS) in elevated intracranial pressure of traumatic brain injury patients. This study was conducted at Mamatha medical college, it includes 20 patients divided into 2 groups; mannitol group (M), and Hypertonic saline(HS)group. A single equimolar infusion (255 mOsm dose) of either 231 ml of 20% mannitol (M)or 100 ml of 7.45% hypertonic saline (HS) administered for 20min. Intracranial pressure, arterial blood pressure, cerebral perfusion pressure,brain tissue oxygen tension, serum sodium and osmolality, and urine output were measured at T0,30,60,90,120 min. The two drugs were efficient in reducing ICP. At 60 mins after the start of theinfusion, ICP was reduced by 44% ±17% of baseline values (mean ± SD) in the mannitol group vs. 33% ±12% of baseline values in the HS group. The CPP was elevated significantly in mannitol group compared to base line values whereas slight elevation was seen in HS group. Significantly greater increase inurine output notice in mannitol than HS, although there was no difference in the vascular filling requirement between the two treatments. HS caused a significant elevation of serum sodium and chlorideat 120 mins after the start of the infusion. It was concluded that equimolar dose of both drugs were effective in treatment of elevated intracranial pressure
Authors and Affiliations
Jagadeesh Babu. K
Keywords
Related Articles
- EP ID EP214042
- DOI -
- Views 71
- Downloads 0
Pseudomyxoma Peritonei
Pseudomyxoma peritonei syndrome is characterized by mucinous ascites and mucinous tumor disseminated on peritoneal surfaces. The disease almost always originates from a perforated appendiceal epithelial tumor. Appendix t...
A Prospective Randomised Study Comparing Crystalloid Preload and Coload in Parturients for Caesarean Section Under Subarachnoid Block
Background and Aim: Regional anaesthesia is usually preferred over general anaesthesia in parturients undergoing caesarian section. Hypotension during spinal anaesthesia for caesarean section is a common complication. He...
Lobulated Spleen: A Cadaveric Study – Segmental Resection of Spleen
Development: Spleen is associated with development of mesogastrium. It develops from the mesoderm during sixth week of intrauterine life Mesenchymal Mass: spleen develops from the mesenchymal cells which proliferate to f...
Role of Neurosonogram in Evaluation of Brain Injuries in Preterm Babies
Background and Objectives: Neuro developmental abnormalities was very common in premature neonates due to incomplete development of the central nervous system. Neurosonogram is a sensitive tool for detecting these abnorm...
Complete Penoscrotal Transposition- A case Report
Penoscrotal transposition is where malposition of penis occur in relation to scrotum. It is frequently associated with malformation of genitourinary, cardiovascular or skeletal system. We report a rare case of complete p...