Marchiafava-Bignami disease induced by chronic alcohol intake

Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 10

Abstract

Abstract:A 42-year-old male admitted to a local psychiatric facility fell unconscious, and his oxygen saturation decreased to 40% on the first hospital day. The medical staff could not respond to this situation and called an ambulance. A doctor car was dispatched and docked with the ambulance. As the patient remained in a deep coma state, he underwent tracheal intubation at the rendezvous point. He had a history of drinking 360 g of ethanol per day. On arrival, he received infusion of vitamin B1. On a physical examination, both eye balls were in the abductor position. A urinary qualitative test for drugs was negative. The level of vitamin B1 was 24.0 (normal range: 21.3-81.9) ng/ml. Whole-body computed tomography (CT) revealed low density at the splenial area, left dorsal consolidation at the left lung and fatty liver changes. Magnetic resonance imaging immediately after CT revealed an isolated splenial lesion. He received a diagnosis of Marchiafava-Bignami disease (MBD), alcoholic hepatitis, alcoholic rhabdomyolysis and aspiration pneumonia. After admission to the intensive-care unit, he underwent infusion of thiamine and antibiotics. On the third hospital day, his respiratory function and consciousness recovered, an extubation was performed. At that time, he had disorientation and dysarthria. After regaining his ability to feed himself, he was transferred to the previous psychiatric facility. He ingested vitamin B1 until transportation. We herein report a rare case of MBD diagnosed based on MRI findings and the patient’s history of alcohol consumption. Immediate and continuous infusion of thiamine is important for MBD even the level of vitamin B1 is the normal range. Keywords:Marchiafava-Bignami disease; thiamine; splenium

Authors and Affiliations

Kei Jitsuiki, Kazuhio Omori, Hiroki Nagasawa, Ikuto Takeuchi, Akihiko Kondo, Kouhei Ishikawa, Youichi Yanagawa

Keywords

Related Articles

Retinal Metastasis of Breast Cancer HER 3+ With Good Response to Trastuzumab, Pertuzumab ET Docetaxel

Retinal metastases are rare and have a very poor prognosis, involving both functional and vital prognosis, reporting the case of a patient who has a retinal metastatic relapse that responds very well to double block Her2...

A Rare Case of Reiter’s Disease

Reiter’s disease is a genetically orchestrated immune response focussed on skin and joints, commonly presenting with a triad of conjuctivitis, acute non supurative seronegative arthritis and urethritis. A 24 year old fem...

Isolated and Displaced Fracture of the Posterior Angle of the Acromion in a Cyclist: Case Report

Acromial fractures are a rare occurrence, very few cases of displaced isolated fractures of the acromion requiring surgical treatment have been reported. We report a case of isolated and displaced fracture of the acromio...

Mucinous Adenocarcinoma of Jejunum: A Rare Malignancy

Abstract: Small bowel malignancy is a rare entity. Adenocarcinoma is a most common histologic subtype. Primary jejunal carcinoma is rare and is difficult to diagnose clinically due to non-specific symptoms. Surgical rese...

Squamous cell Carcinoma of the Eye in a Xeroderma pigmentosum Child

Xeroderma pigmentosum (xp) is a rare autosomal recessive disorder, characterized by photosensitivity, pigmentary changes, premature skin aging and marked increase in risk of developing malignant tumor development. We rep...

Download PDF file
  • EP ID EP379349
  • DOI -
  • Views 93
  • Downloads 0

How To Cite

Kei Jitsuiki, Kazuhio Omori, Hiroki Nagasawa, Ikuto Takeuchi, Akihiko Kondo, Kouhei Ishikawa, Youichi Yanagawa (2017). Marchiafava-Bignami disease induced by chronic alcohol intake. Scholars Journal of Medical Case Reports, 5(10), 639-641. https://europub.co.uk/articles/-A-379349