Marchiafavae Bignami Disease in Chronic Alcoholic Patient
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Marchiafava-Bignami disease (MBD) is a rare, alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. It is mostly seen in male alcoholics. It is caused by the combination of alcohol abuse with malnutrition, leading to metabolic, toxic, and vascular disturbances. MBD carries poor prognosis. There are 2 clinical subtypes- TYPE A where patient mainly presents with coma and stupor has a mortality of 90%; TYPE B, which of lesser severity and presents with only mild mental impairment. Clinical symptoms include reduced consciousness, psychotic and emotional symptoms, depression and apathy, aggression. Diagnosis of the disease is made on the basis of clinical findings in combination with neuro imaging. Treatment options tried include thiamine, folate and VITAMIN B12, amantadine and high dose corticosteroids have been tried with limited success. We present a patient who presented with acute onset symptoms and typical Imaging findings findings.
Authors and Affiliations
Kiran Bheemeshwar
Keywords
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