MARKERS OF LIPID AND PROTEIN OXIDATION IN THE BLOOD OF WOMEN AND MEN WITH AUTOIMMUNE HASHIMOTO'S THYROIDITIS
Journal Title: Biota. Human. Technology - Year 2024, Vol 1, Issue 1
Abstract
Purpose: The aim of this study was to analyze changes in markers of oxidative stress (lipid peroxidation and oxidative modification of proteins) and the total antioxidant capacity in the blood of women and men with autoimmune Hashimoto's thyroiditis (HT). Methodology. This study was carried out in a group of 153 individuals. The group of women participating in the study consisted of 109 individuals (71.24%), while the group of men consisted of 44 individuals (28.76%). All persons were divided into two groups: 1) euthyroidism (n = 64; men –n = 18, and women –n = 46); and 2) Hashimoto's autoimmune thyroiditis with subclinical hypothyroidism (n = 89; men –n = 26, and women –n = 63). The functioning of the thyroid gland was additionally verified by measuring the concentration of thyrotropin (TSH), free triiodothyronine (fT3), free tetraiodothyronine (thyroxine, fT4), and antibodies against thyroid peroxidase (anti-TPO). The concentration of thyrotropin, triiodothyronine, free thyroxine and the concentration of antibodies against thyroperoxidase in human serum were determined using the electrochemiluminescence method "ECLIA" on the immunological analyzer Elecsys Cobas e 411 (Hitachi, Japan). In each group of women and men with euthyroidism and Hashimoto's autoimmune thyroiditis with subclinical hypothyroidism, the 2-thiobarbituric acid reactive substances (TBARS), carbonyl derivatives of protein oxidative modification (OMP), and total antioxidant capacity (TAC) were determined.Scientific novelty. Statistically significant changes in levels of oxidative stress markers were not observed. In women with HT, elevated TBARS levels with simultaneously increased TAC levels in the plasma and erythrocytes were observed. Additionally, levels of aldehydic and ketonic derivatives of oxidative modification of proteins in the blood of women with HT were lower compared to the women with the euthyroid state. In men with HT, levels of markers of oxidative stress (except TAC levels in the plasma) were lower compared to those obtained in men with the euthyroid state.Conclusions. Hashimoto's thyroiditis with subclinical hypothyroidism does not have a direct influence on levels of biomarkers of lipid and protein oxidation. The results obtained in the current study highlight the need for future investigationsof biomarkers of lipid and protein oxidation, especially depending on the duration of this disease.
Authors and Affiliations
Halina Tkaczenko, Urszula Osmólska, Natalia Kurhaluk
Keywords
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- EP ID EP753572
- DOI https://doi.org/10.58407/bht.1.24.10
- Views 26
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