Markers of Oxidative Stress in Generalized Anxiety Psychiatric Disorder: Therapeutic Implications
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2012, Vol 8, Issue 2
Abstract
There is growing evidence that oxidative stress contributes to the pathogenesis of anxiety disorders. Our aim was to measure oxidative stress in anxiety disorders subjects, and assesses the potential confounding influences of anti anxiety therapy. Serum malondialdehyde and antioxidant levels were estimated in patients at the time of presentation and also after anti- anxiety therapy for 3 months. During the period of study no antioxidant/s was given to the patients and control subjects. Serum malondialdehyde levels were significantly higher in the anxiety disorders patients in comparison to control cases. Also, the antioxidant activity of enzymes super oxide dismutase, glutathione and non enzymatic antioxidant levels of vitamins E and C were significantly lower in patients compared to controls at the initial presentation. After 3 months of anti anxiety treatment all the above parameters showed reversal in the respective levels of serum malondialdehyde and antioxidant activity. Anti anxiety medications results in reduced oxidative stress which indicates that oxidative stress is not the cause, but rather a consequence, of anxiety disorders.
Authors and Affiliations
Ranjana Khanna, Reena Negi, Deepti Pande, Shruti Khanna, Hari Khanna
Keywords
Related Articles
- EP ID EP86774
- DOI -
- Views 141
- Downloads 0
Salinity stress effects changed during Aloe vera L. vegetative growth
Salt stress is a limiting factor of plant growth and yield, and becoming a serious problem in the world so in reason to determine salinity effect on aloe growth experiment was conducted in a greenhouse as a bi-factorial...
Effect of controlled irrigation on physiological and biometric characteristics in teak (Tectona grandis) seedlings
Effect of controlled irrigation in physiological and biometric characteristics in teak seedlings is monitored at Forestry College in Kerala, India. Six month old seedlings of Teak ([i]Tectona grandis[/i] L. f.) were rais...
Seasonal Dynamics of Stress Proteins in Leaves of Medicinal Plants in a Natural Environment of Irkutsk and on the Shores of the Lake Baikal
We study leafs of five plant species, growing in Irkutsk city and on the southeastern shore of Lake Baikal. These species are [i]Achillea asiatica[/i] Serg., [i]Taraxacum officinale[/i] Wigg., [i]Plantago major[/i] L., [...
GENETICS AND GENOMICS OF PLANT GENETIC RESOURCES
Biochemical Response of Glycine max (L.) Merr. to Cobalt and Lead stress
[b]Background:[/b] Heavy metal pollution of soil has become a global concern, largely due to the fact that the heavy metals accumulated in plants may either directly or indirectly find their way into animals and human be...