Markers of severity of heart failure in the elderly.
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2009, Vol 1, Issue 2
Abstract
Objective: To determine the possible correlation of NYHA classification with clinical and paraclinical parameters in elderly diagnosed with heart failure. Material and methods: Patients aged over 65 years, diagnosed with heart failure, were included in study. Clinical data, biochemical markers and imagistic parameters were determined, and the presence or absence of comorbidities was noted. Results: A number of 178 patients were included in study. In univariate analysis, NYHA classification was associated with: orthopnea, jugular venous distention, rales, bilateral ankle edema, pleural effusion, hepatomegaly, atrial fibrillation, estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), C-reactive protein (CRP), high-density lipoprotein cholesterol (HDL-cholesterol), and left ventricle ejection fraction (LVEF). The multivariate analysis showed the independent markers linked to NYHA classification: presence of orthopnea (p<0.001), bilateral ankle edema (p=0.05), chronic kidney disease (p=0.05), high levels of CRP (p=0.04) and altered LVEF (p=0.02). Conclusion: Orthopnea, bilateral ankle edema, renal dysfunction, inflammation and low LVEF are correlated with NYHA classification.
Authors and Affiliations
Antonia Macarie, Valer Donca, Stefan Vesa
Keywords
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