Marketplace Analysis of Conjugated Estrogens: Determining the Consistently Present Steroidal Content with LC-MS
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 6
Abstract
The online version of this article (doi:10.1208/s12248-015-9805-x) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Michaella J. Levy, Michael T. Boyne, II, Sarah Rogstad, David J. Skanchy, Xiaohui Jiang, Ilan Geerlof-Vidavsky
Shear-induced variability in the United States pharmacopeia apparatus 2: Modifications to the existing system
The hydrodynamics within the United States Pharmacopeia Apparatus 2 have been shown to be highly non-uniform with a potential to yield substantial variability in dissolution rate measurements. Through the use of readily...
Bioinformatic analysis of the human μ opioid receptor (OPRM1) splice and polymorphic variants
Mu opioid receptor (OPRM1), a member of the G-protein coupled receptor superfamily, mediates the analgesic and euphoric effects of opioid drugs. The sequences of OPRM1 cDNA and reported splice variants were used to searc...
Serotonin transporters: Implications for antidepressant drug development
Due to the complexity of the disease, several hypotheses exist to explain the etiology of depression. The monoamine theory of depression suggests that disruptions in the serotonergic and noradrenergic systems result in d...
Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions
Empirical Bayes (“post hoc”) estimates (EBEs) of ηs provide modelers with diagnostics: the EBEs themselves, individual prediction (IPRED), and residual errors (individual weighted residual (IWRES)...
Cutaneous Microdialysis: Cytokine Evidence for Altered Innate Reactivity in the Skin of Psoriasis Patients?
The online version of this article (doi:10.1208/s12248-012-9331-z) contains supplementary material, which is available to authorized users.