Mass Spectrometry Screening Reveals Peptides Modulated Differentially in the Medial Prefrontal Cortex of Rats with Disparate Initial Sensitivity to Cocaine
Journal Title: The AAPS Journal - Year 2010, Vol 12, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-010-9204-2) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Elena V. Romanova, Ji Eun Lee, Neil L. Kelleher, Jonathan V. Sweedler, Joshua M. Gulley
NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
Sirtuins are recently discovered NAD+-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins, thereby regulating the biological function of their targets. Sirtuins have been shown to increas...
The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family
The online version of this article (doi:10.1208/s12248-014-9649-9) contains supplementary material, which is available to authorized users.
Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences
Baicalein (Ba) was found to be subject to serious first-pass metabolism after oral administration. We previously revealed the important role of intestine in the low oral bioavailability of Ba. The present study aims to e...
Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products
This review presents considerations which can be employed during the development of a semi-solid topical generic product. This includes a discussion on the implementation of quality by design concepts during development...
Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water
The online version of this article (doi:10.1208/s12248-015-9729-5) contains supplementary material, which is available to authorized users.