MAST CELLS AND ANGIOGENESIS IN ORAL EPITHELIAL DYSPLASTIC LESIONS AND ORAL SQUAMOUS CELL CARCINOMA
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Background: The progression of oral epithelial dysplastic lesions into oral squamous cell carcinoma is characterized by an ‘angiogenic switch’ which is characterized by an increase in neo-vascularization in the subepithelial lamina propria which can be considered an indicator of malignant transformation. Mast cells are a rich source of various angiogenic factors. Moreover mast cells secrete various proteolytic enzymes which degrade the extracellular matrix and create space for the developing blood vessels. Aims: This study was undertaken to determine the relationship between mast cell density and microvessel density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma and to find out whether any correlation exists between these two parameters. Material and Methods: This retrospective study was performed using formalin fixed, paraffin embedded tissues of previously diagnosed cases of oral epithelial dysplasia and oral squamous cell carcinoma. Mast cells were stained using toluidine blue, whereas in the capillaries, immunohistochemical staining technique was performed using mouse monoclonal antibody against CD34. Results: Mast cell density and microvessel density were higher in oral epithelial dysplasia and in oral squamous cell carcinoma compared to the normal mucosa. However, statistically significant positive correlation was noted only in oral epithelial dysplasia Conclusion: The above results probably indicate a role of mast cells in ‘angiogenic switch’. These angiogenic factors secreted by mast cells promote angiogenesis either directly by stimulating the migration and/or proliferation of mast cells or indirectly through degradation of extracellular matrix. Targeting the mast cells may contribute in preventing the progression of the lesion.
Authors and Affiliations
Hegde Veda| Associate Professor, Department of Oral Pathology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India, Corresponding author email: hegdeveda6@rediffmail.com, Marla Vinay| Post Graduate Student, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, India
Keywords
Related Articles
- EP ID EP11342
- DOI 10.5958/2319-5886.2015.00008.9
- Views 312
- Downloads 11
Different methods to evaluate mandibular alveolar ridge in Cone Beam Computed Tomography images in pre-implant surgery assessments
Presently in our country, the measurement ofalveolar bone in Cone Beam Computed Tomography (CBCT) images is done by oral and maxillofacial radiologists. Most of theclinicians in implant treatment plan,use the measuremen...
LIVER FUNCTION BIOMAKERS IN MALARIA AND HEPATITIS B CO-INFECTION AMONG PATIENTS WITH FEBRILE ILLNESS
Introduction: Malaria and Hepatitis B Virus (HBV) co-infections present major threat to public health throughout tropical and Sub-Saharan Africa. This study was carried out to analyze the status of liver enzymes and se...
THE DIAGNOSTIC UTILITY OF CELL BLOCK AS AN ADJUNCT TO CYTOLOGICAL SMEARS
Objectives: Cytological examination of serous fluids is of paramount importance in detecting cancer cells. Distinguishing malignant cells from benign reactive mesothelial cells in fluid cytology is an everyday diagnosti...
PREVALENCE OF EMOTIONAL DISTRESS IN CAREGIVER’S OF CANCER PATIENTS
Background: A diagnosis of cancer is an intensely stressful experience for patients. How much it affects the caregiver’s is not apparent as it leads to hidden Co morbidity in the persons involved in the care giving pr...
CLINICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN OF TYPHOID FEVER IN PATIENTS ADMITTED TO PEDIATRIC WARD IN A RURAL TEACHING HOSPITAL
Introduction: Typhoid is a major endemic health problem among children in India. The last two decades have witnessed the emergence and spread of multidrug resistance against conventional anti typhoid drugs (Ampicillin,...