Maternal and Fetal Toxicity of Carisoprodol
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 1
Abstract
Aim of the work: this study aimed to detect the histological and histochemical changes in liver tissue of pregnant rats and their fetuses after treatment with carisoprodol. Material and methods: thirty pregnant female rats were randomly categorized into three groups (ten pregnant female rats in each group). The first was administered oral doses of distilled water and was served as control. The other two groups were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for 15 days from the 6th day to the 20th day of gestation. Numerous histological and histochemical studies were done to detect the histopathological and histochemical changes. Results: maternal and fetal liver tissue of both treated groups showed lots of degenerative changes post-treatment withcarisoprodol. The severity of these changes was more obvious in fetal liver tissue of both groups this was accompanied with numerous histochemical changes. Conclusion: treatment of pregnant rats withcarisoprodol led to numerous dystrophic changes in maternal and fetal liver tissue.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP555715
- DOI -
- Views 173
- Downloads 0
Beliefs on Influenza Disease and Vaccine among Health Care Workers in Jeddah, Saudi Arabia
<strong>Background: </strong>Seasonal influenza is considered to be a serious public health problem that may cause death in high risk population. It is very important for healthcare workers who are in direct contact with...
Gastroesophageal Reflux Disease among Pilgrims during the Hajj Period (1438 Hegira): Prevalence and Impact on the Quality of Life
<strong>Background: </strong>Gastroesophageal reflux disease (GERD) is a chronic motility disorder resulting in reflux of stomach contents in to the esophagus. It has a prevalence rate of 10-20% in the western world. In...
Evaluation of Fixation of Mastectomy Flaps in Reduction of Seroma Formation in Breast Cancer Patients
<span>Background: </span><span>Seroma is the most common complication following modified radical mastectomy (MRM), as post mastectomy dead space left between skin and anterior chest wall where seroma is formed causing mu...
Estimation of Serum Ferritin Level in Preterm Labour
Background: Preterm birth is the leading cause of newborn deaths and also the leading cause of death in children under 5 years of age. There is wide spread suspicion that subclinical infection is a common accompaniment a...
Assessment of Left Atrial Function in Patients with Non-ST-Segment Elevation Myocardial Infarction Using Two-Dimensional Speckle Tracking Echocardiography
<strong>Background</strong>: the left atrium (LA) plays a major role in Left ventricular (LV) performance. LA function is a surrogate marker of LV diastolic dysfunction. LA mechanical dysfunction occurs in LV systolic an...