Maternal Lipid Profile as A Risk Factor for Preeclampsia
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 6
Abstract
<span>Background: </span><span>Preeclampsia occurs in about 3-5% of pregnancies and is an important cause of fetal and maternal morbidity and mortality worldwide</span><span>. </span><span>Preeclampsia occurs during second and third trimester of pregnancy, and it is more common in nulliparous women. It is characterized by blood pressure of 140/90 mmHg or rise in systolic blood pressure of more than 30 mmHg or diastolic blood pressure of more than 15 mmHg after 20 weeks of gestation, in conjugation with proteinuria >300 mg/24 hours or greater or equal to 1+ or 100 mg/dl by dipstick response</span><span>. </span><span>Hypertriglyceridemia is traditionally defined as a serum or plasma triglyceride (TG) concentration above 1.6 mmol/l. It is found in 13% of woman aged 20-40 years</span><span>. </span><span>Objectives: </span><span>Assessing the changes in lipid profile in preeclampsia and as a marker of severity of the condition. </span><span>Patients and Methods: </span><span>This was a control study conducted at Al-Hussien and Air Force Hospitals during the period from December 2016 to May 2017. Total 100 pregnant women of 18-36 years in the 2</span><span>nd </span><span>half of pregnancy (>20 weeks of gestation) were selected and grouped as follows. Group-I (Controls): 40 Normotensive pregnant women; Group-II 30 Mild pre-eclamptic pregnant women and Group-III 30 severe pre-eclamptic pregnant women. </span><span>Conclusion: </span><span>Preeclampsia has an association with hypertriglyceridemia, and elevated cholesterol level, LDL and VLDL, and decreased HDL level. The more the severity of preeclampsia the higher was the level of serum triglycerides, cholesterol, LDL and VLDL, and the lower the HDL.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
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