Maternal thyroid dysfunction and neonatal cardiac disorders
Journal Title: Insights in Biology and Medicine - Year 2017, Vol 1, Issue 1
Abstract
The normal levels of thyroid hormones (THs; thyroxine, T4 & 3,5,3′-triiodo-L-thyronine, T3) are necessary for the normal development [1-48], particularly the fetal and neonatal cardiac growth and development [49]. The actions of THs are facilitated genomically by thyroid receptors (TRs, α and β) and non-genomically at the plasma membrane, in the cytoplasm and in cellular organelles [4,49-55], by stimulation of Na+, K+, Ca2+ and glucose transport, activation of protein kinase C (PKC), protein kinase A (PKA) and mitogen activated and protein kinase (ERK/MAPK) [4].
Authors and Affiliations
Ahmed RG
Keywords
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- EP ID EP556887
- DOI 10.29328/journal.ibm.1001008
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