Mean Platelet Volume as an Independent Risk Factor for Acute Myocardial Infarction and Its Short Term Prognostic Significance
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Background of study: The biological events that occur in the Coronary system immediately preceding acute coronary syndromes are still unclear. However platelets are definitely involved, and changes in platelet structure may be a casual factor in producing a thrombus in the coronary artery. Platelet activation, by favouring thrombus formation and coronary artery occlusion is thought to play a key pathogenic role in acute myocardial infarction1 It has been shown that platelet size, measured as mean platelet volume (MPV) correlates with their reactivity3 . Circulating platelets are heterogeneous in size density and reactivity10 . Platelet age & size are independent determinants of platelet function5 . Mean platelet volume is positively associated with indicators of platelet activity including expression of glycoprotein 1b and glycoprotein IIb/IIIa receptor on many studies. Elevated MPV has been recognised as independent risk factor for myocardial infarction6, In acute stages of platelet activation, an increase in platelet volume might be a result of a change in fragmentation pattern of megakaryocyte. The goal of the study was to assess MPV in patients with acute myocardial infarction (AMI) admitted within 3 hours of chest pain, and its short term prognostic significance.
Authors and Affiliations
Dr Ajitha Kesi Chellappan
Keywords
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