Mean platelet volume as short-term follow-up biomarker in children with celiac disease
Journal Title: Indian Journal of Child Health - Year 2017, Vol 4, Issue 4
Abstract
Objective: To assess the mean platelet volume (MPV) as a short-term follow-up biomarker in celiac disease (CD) and to compare it with anti-tissue transglutaminase antibody (TTGA) assay in Indian children. Material and Methods: Newly diagnosed 35 children aged <12 years who were positive for TTGA and further confirmed by intestinal biopsy with histological Grade 2 and 3 based on modified Marsh Classification were enrolled. TTGA, MPV, and clinical parameters were assessed at enrollment and after 3 months of gluten free diet (GFD). Results: Short stature (94.3%) and diarrhea (80%) were the most common presenting features. 33 (94.3%) children were found to have anemia. MPV reduced significantly from 9.28±1.88 fl to 8.55±1.10 fl after 3 months of GFD, (p<0.001). The mean TTG level reduced from 166.80±59.23 U/ml to 86.45±39.67 U/ml (p<0.001) after 3 months of GFD. Conclusion: MPV is one of the biomarkers that can be used to monitor dietary transgressions in CD in short term.
Authors and Affiliations
Mohanaraj Ramachandran, Anurag Agarwal, R N Mandal Ravi, K Rajeshwari, Avinash Lomash, Seema Kapoor
Clinicopsychological profile of children with bleeding disorders from a tertiary center in Karnataka
Objectives: The aim of this study is to observe the clinical spectrum of presentation of hemophilia and other bleeding disorders in children. Material and Methods: This observational study was carried out in the Comprehe...
Iron status among under-five children with first febrile convulsion and subsequent febrile convulsion
Objective: The objective of this study is to estimate the iron status using hemoglobin (Hb), red cell indices, serum iron, plasma ferritin, total iron binding capacity (TIBC), and transferrin saturation (TSAT) in childre...
Study of incidence of hypocalcemia in infants admitted with seizures in a tertiary care hospital
Background: During growth, bone mass increases faster than the body weight, which results in increased demand of calcium. Hypocalcemia, seen in postneonatal infants, is related to poor oral intake, low level of Vitamin-D...
Correlation of acute suppurative otitis media with infant feeding position
Background: Acute otitis media (AOM) is the most common childhood illness necessitating medical therapy for children younger than 5 years. Long-term and exclusive breastfeeding is associated with protection against AOM....
Clinical profile of children with Fanconi anemia from a tertiary center in Southern India
Objectives: The aim of this study is to observe the clinical spectrum of presentation of Fanconi anemia (FA) in children presenting to the Hematology Department of Victoria Hospital, Bangalore Medical College and Researc...