Mean Platelet Volume to Platelet ratio as a promising marker of hepatosteatosis
Journal Title: Experimental Biomedical Research - Year 2018, Vol 1, Issue 1
Abstract
Aim: Hepatosteatosis confers increased lipid accumulation in the hepatocytes which is associated with inflammation. Hemogram parameters, such as mean platelet volume (MPV) and MPV to platelet ratio (MPR) are proposed as novel inflammatory markers in recent studies. We aimed to compare MPR of subjects with hepatosteatosis to those in healthy controls. Methods: Patient admissions to our clinic with a diagnosis of hepatosteatosis were retrospectively analyzed MPR values compared to those in healthy controls. Results: Mean MPR of hepatosteatosis group (0,04 ± 0,01fL/mm3) was significantly higher than the MPR of control subjects (0,03 ± 0,01 fL/mm3) (p=0.04). A Pearson’s Correlation analyze was revealed significant correlations between MPR and fasting plasma glucose (r=0.26, p=0.004) and between MPR and LDL-cholesterol (r=0.19, p=0.04). Conclusion: An elevated MPR should alert physicians for hepatosteatosis in otherwise healthy subjects. Therefore, calculation of MPR by automatic hemogram analyzers is advised.
Authors and Affiliations
Mehmet Ali Kosekli, Edip Erkus, Mehmet Zahid Kocak
Keywords
Related Articles
- EP ID EP50803
- DOI https://doi.org/10.30714/j-ebr.2018237497
- Views 361
- Downloads 0
Roles of the systemic inflammatory response biomarkers in the diagnosis of cancer patients with solid tumors
Aim: Cancer is still considered as one of the leading causes of mortality worldwide. Various tumor factors have been used for the diagnosis and follow-up of solid tumors; however, their clinical features remains controve...
Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats
Aim: To investigate the effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion (I/R) in rats. Method: Forty male Wistar rats were randomly divided into 4 gr...
Is it necessary to perform an endometrial sampling prior to hysterectomies for benign conditions?
Aim: Hysterectomy is one of the most prevalent surgical intervention in gynecological field. This study concerns the requirement and necessity of an endometrial sampling to exclude an unpredictable uterine malignancy ris...
Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model
Aim: To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemia-reperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental stu...
Thyroid fine needle aspiration reporting rates and outcomes before and after Bethesda implementation: A single-center experience over 8 years
Aimː To evaluate data from our hospital system before and after the implementation of the Bethesda System for Reporting Thyroid Cytology (TBSRTC) and comparison of our data with the previously published studies. Metho...