Measurement of Activity of Glutathione Peroxidase (Gpx) and Superoxide Dismutase (SOD) in Upper Gastrointestinal Cancer Patients
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Purpose: Measurement of activity of Glutathione peroxidase (Gpx) and Superoxide dismutase (SOD) in Upper Gastrointestinal Cancer Patients. Methods: For the study comprising total 30 cases suffering from esophagus cancer and 30 cases suffering from stomach cancer were selected. All patients were clinically and histologically diagnosed. A total of 50 age and sex matched healthy subjects taken as control. The circulating levels of SOD and GPx activity were assayed in the in the serum of control group and in patients with Upper GIT cancer. Results: Mean SOD and Gpx activity in serum were significantly decreased in upper GIT cancer patients as compared to control (p<0.001). Conclusion: In the present study I concluded that the activity of SOD and Gpx were significantly decreased found in upper gastrointestinal cancer patients because reactive oxygen species (ROS) are generated through numerous normal metabolic processes and are needed for normal functioning of the organism. Various antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx) control their accumulation. Oxidative stress caused by increased free radical generation and decreased antioxidant level in the target cells and tissues has been suggested to play an important role in carcinogenesis. In this study antioxidant enzyme SOD with and Gpx shows positive correlation.
Authors and Affiliations
Ravindra Kulkarni, Manjjari Kulkarni
Keywords
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- EP ID EP547779
- DOI 10.21276/ijmrp.2017.3.3.009
- Views 59
- Downloads 0
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