MEASURING HEMODYNAMIC RESPONSE IN DIRECT LARYNGOSCOPY AND INTUBATIONEFFECTS OF ORAL CLONIDINE VERSUS SUBLINGUAL NIFEDIPINE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 31
Abstract
BACKGROUND In endotracheal anaesthesia, tracheal intubation can have undesirable cardiovascular events. With no effect in normal healthy persons, these deleterious effects in patients with hypertension, raised intracranial pressure, raised intraocular pressure and coronary arterial disease. This procedure requires a safe drug which negates all these undesirable effects, which are transient in nature. METHODS A prospective study was carried out from June 2008 to August 2010 in S.V. Medical College and SVRRGG Hospital, among patients posted for surgery under general anaesthesia, after satisfying the inclusion and exclusion criteria. Patients were randomized into two groups Clonidine and Nifedipine groups. Patients were evaluated for blood pressure, SpO2, pulse, ECG during the study. RESULTS We observed a sharp but mild decrease in pulse rate in Clonidine group, but in all, pulse rate in the patients remains the same all over the duration of surgery. There was elevation in pulse rate in Nifedipine group, in all measured time intervals. Mean arterial blood pressure, systolic blood pressure and diastolic blood pressure in Clonidine group remain the same through all the time intervals measured, but in Nifedipine group it decreases slightly. The fall in mean arterial blood pressure, systolic blood pressure and diastolic blood pressure in the Nifedipine group made it necessary for constant vigil of hemodynamic monitoring during the general anaesthesia. We did not encounter any observed complications in the study. CONCLUSIONS Nifedipine group shows rise in Mean Arterial Pressure during intubation but a sustained fall later. Clonidine group shows decrease in Mean Arterial Pressure, Blood Pressure after laryngoscopy and continues throughout procedure.
Authors and Affiliations
Yedoti Vijayakumari
Keywords
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- EP ID EP670412
- DOI 10.18410/jebmh/2019/434
- Views 84
- Downloads 0
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