We report a rare case of large bowel obstruction caused by locally advanced pancreatic tail adenocarcinoma. A 58-year-old male chronic smoker presented with progressive abdominal distention and absolute constipation for three weeks without nausea or vomiting. On examination he appeared cachectic with a grossly distended tympanic and tender abdomen while rectal examination was unremarkable. A CT scan revealed diffuse bowel dilatation with a transition zone at the splenic flexure. Emergency exploratory laparotomy identified a mass involving the left colonic flexure spleen and pancreatic tail. The patient underwent a left hemicolectomy splenectomy and distal pancreatectomy with the creation of stoma. Histopathology confirmed ductal adenocarcinoma originating in the pancreatic tail with invasion into the colon and spleen. Postoperatively he developed hospital-acquired pneumonia which resolved with antibiotics and was discharged on day 21. Unfortunately he succumbed to recurrent pneumonia with severe sepsis one week later. Although rare pancreatic adenocarcinoma should be considered in the differential diagnosis of large bowel obstruction.