Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 2
Abstract
The online version of this article (doi:10.1208/s12248-012-9343-8) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbell
Keywords
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- EP ID EP681213
- DOI 10.1208/s12248-012-9343-8
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Holford NHG and Sheiner LB “Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models”, Clin Pharmacokin 6:429–453 (1981)—The Backstory
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