Mechanism of Action of Nerve Growth Factor Induced Histamine Release from Mast Cells during the Inflammation Process
Journal Title: Advances in Clinical Toxicology - Year 2023, Vol 8, Issue 1
Abstract
Mast cells and the biogenic amine, histamine, play a central role in inflammatory reactions. Nerve growth factor (NGF) is essetial for the survival of neurones and has significant role in inflammation and repair of tissues. It has been shown, that NGF induces degranulation of mast cells by interacting with tropomyosine-receptor kinase A (TrkA receptor). NGF can induce release of histamine and other mediators from mast cells or enhance secretion induced by different stimuli. The results of our and others previous studies show, that histamine release from mast cells induced by NGF is strongly dependent on the concentration of extracellular Na+, Ca2+ ions. The extracellular Na+ ions can affect the activity of Na+/Ca2+ exchanger of mast cells. Na+, Ca2+ exchange mechanisms could be important in secretory process of mast cells. The studies of different signaling molecules in NGF induced histamine relese have shown that tyrosine kinase, phosphatidylinositol-3-kinase, protein kinase C and phospholipase C are also involved in the signal transduction process responsible for NGF induced histamine secretion from mast cells. These data indicate that NGF may contribute in allergic reactions and many other inflammatory states.
Authors and Affiliations
Ferjan I*
Keywords
Related Articles
- EP ID EP752055
- DOI 10.23880/act-16000255
- Views 22
- Downloads 0
Assessment of the Effects of Antiretroviral Medications on Kidney Status in Rwanda
According to the previous research, ART over different durations of time has an effect on the nephron as well as on liver hepatoxicity by inducing toxicity. Renal dysfunction by ART has been associated primarily with ten...
Malaria Tests-DNA PCR and Quantitative Buffy Coat (QBC)
Malaria, considered a tropical disease, poses a significant threat to public health especially in Sub-Saharan Africa [1]. It is a blood borne disease caused by a protozoan parasite called plasmodium [1,2]. Being blood...
Cardiovascular Complications during COVID-19 Infection
In December 2019 a serious outbreak of pneumonia emerged in china. The infection Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), spreads the infection rapidly...
Case Report (Acute Iron Toxicity)
Acute poisoning is a critical situation that needs rapid history taking, investigations and quick intervention at the Poison Control ER. Best treatment protocols should be started as soon as a diagnosis is made, but gen...
Retrospective Study of Snakebites in Nawalpur Snakebite Treatment Center, South-central Nepal
Snakebite is a pronounced health problem in the rural tropics and the subtropics of Nepal. However, only fragmentary hospital-based epidemiological data are available. We aimed to determine the incidence of snakebites a...