Mechanism of Inflammatory Pain and Implementation of Natural Products as Rescue Route
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 6
Abstract
The onset of pain is the major discomfort associated with inflammation. The inflammation is usually associated with tissue injury, irritation and infection. This leads to the release of pro-inflammatory compounds from either damaged or immune cells leading to the stimulation of nociceptors which are mainly primary afferent fibres. The stimulation of these fibres by neuropeptide, substance P, prostaglandins, leukotrienes, histamine, serotonin, protons and others leads to pain. To ease this pain, the drugs tend to either inhibit the enzymes or the nerve receptors. The major means of controlling the pain involves the inhibition of cyclooxygenase and lipoxygenase pathways. However, the effective inhibition of these enzymes tends also to impede other functional physiological activities occurring in the body, leading to health crisis. The steps in eradicating these lethal side effects have led to the various techniques including natural remedies like plants and fish oils. Therefore, this study tends to present a review on the pain sensation pathway during inflammation and how the introduction of natural products in drug therapies could prove lucrative.
Authors and Affiliations
David Adeiza Otohinoyi, Olugbenga Morebise, Adegbenro Omotuyi, John Fakoya
Keywords
Related Articles
- EP ID EP183435
- DOI -
- Views 88
- Downloads 0
Arteriovenous Malformation of the Oral Cavity: A Case Report and Review of Literature
Arteriovenous malformations (AVMs) are developmental vascular anomalies that occur when the embryonic vascular network fails to differentiate. It is composed of abnormal communications between arteries and veins without...
The Protective Effect of Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on Isoproterenol-Induced Acute Myocardial Infarction in Rats
Salivae miltiorrhizae liguspyragine hydrochloride and glucose injection (SGI) are widely used in the clinical treatment of ischemic cerebrovascular diseases, but researches on the prevention and treatment of acute myocar...
Review on Pressure Sores
Pressure sore is a localised injury to the skin and underlying tissue caused due to unrelieved pressure on pressure points or bony prominences. The predisposing factors causing pressure ulcers are both intrinsic and extr...
Symptoms and Management of Glue Ear in School Going Children: A Prospective Study
Aims To document clinical profile (presenting manifestation, hearing assessment) of persistent otitis media with effusion (OME) with hearing impairment in children. To compare the improvement in hearing after non-surgica...
Post-Traumatic Stress Disorder A Case Study
Post traumatic stress disorder is a set of reaction to an extreme stressor such as intense fear, helplessness or horror that leads the individual to relieve the trauma. The disorder may occur at any age1. Symptoms may be...