MECHANISMS OF ACTION OF SOME ANTIDEPRESSANTS AND THEIR EFFICACY IN THE TREATMENT OF DEPRESSION
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 7
Abstract
Depression is a moody condition linked with imbalance of neurotransmitter. In recent time depression is becoming one of the most prevalent public health problems. Abusive drugs, certain medication and life events such as financial difficulties, lost of loved ones are some causes of depression. In this review we focused on the mechanisms of actions and efficacy of some antidepressant in the treatment of depression. Data were identified from online search of current and past reviewed literatures on depression with emphasis on the classes of antidepressants. The Monoamine Oxidase inhibitor (MAOI), Selective serotonin reuptake inhibitors (SSRIs), Serotonin Noradrenaline reuptake inhibitors (SNRIs), and Serotonin receptor antagonists were the major classes of antidepressant discussed. In Conclusion, the classes of antidepressant used in treatment of depression exert their mechanism of action on the central nervous with mild or severe effects on other system.
Authors and Affiliations
Gregory Elayeche Oko
Keywords
Related Articles
- EP ID EP627404
- DOI -
- Views 136
- Downloads 0
PREVALENCE AND POSSIBLE RISK FACTORS ASSOCIATED WITH OVERWEIGHT AND OBESITY AMONG ADULTS IN MAYO AREA IN KHARTOUM STATE-SUDAN
This is a descriptive cross - sectional community based study, was carried out among adults in Mayo area in Khartoum State - Sudan, aims to estimate the prevalence of and to identify the possible risk factors associated...
SURGICAL MANAGEMENT OF PAGET’S DISEASE OF THE VULVA: A CASE REPORT
Extra-mammary Paget disease (EMPD) is one of the rare neoplastic conditions of the skin that accounts for less than 1% of the vulvar malignancies. The condition typically presents as a red, velvety, pruritic skin rash of...
QUANTUM MODELING TO DETERMINE THE CARCINOGENIC POTENTIAL OF AFLATOXIN B2 PRODUCED BY ASPERGILLUS FLAVUS AND A. PARASITICUS
Aflatoxin B2 (AFB2) is produced mainly by the mycotoxin Aspergillus flavus and, Aspergillus parasiticus. Aflatoxins are toxic substances produced by some types of fungi that can grow in food. People who eat foods that co...
THE INFLUENCE OF GENDER ON ENTREPRENEURIAL ORIENTATION OF COMMUNITY PHARMACISTS
Community pharmacists encounter several challenges in the course of practice but these are perceived by some as opportunities which can be converted to economic gains based on entrepreneurial orientations. The study seek...
PHYTOCHEMISTRY AND ACTIVITY VASODILATOR OF SHEETS OF SPONDIAS MOMBIN L. (ANACARDIACEAE)
The physiological study of the vasodilator activity of the ethanol-water extract of dried powdered leaves of the Spondias mombin L. showed vasorelaxant activity (EC50 of 90 mg / L) endothelium-dependent of NO and EDHF va...