Mechanisms of Cinnamomi Ramulus for coronary heart disease treatment: prediction based on network pharmacology
Journal Title: TMR Integrative Medicine - Year 2021, Vol 5, Issue 11
Abstract
Objective: Guizhi (Cinnamomi Ramulus) has been widely applied in treating coronary heart disease in traditional Chinese medicine. However, little is known about the potential mechanism. Elucidating the effective components and mechanism based on network pharmacology was our purpose. Methods: Traditional Chinese Medicine Systems Pharmacology was screened to collect the possible active ingredients and their CAS and SMILES was searched in Pubchem, and the related potential targets were further predicted in Swiss Target Prediction database. Coronary heart disease molecular members were gained from GeenCards database, and the predicted targets of Cinnamomi Ramulus for coronary heart disease’s treatment were selected by Wayne diagram. As for mechanism analysis, String was used to construct the protein-protein interactions, and DAVID was used to conduct the GO and KEGG analysis. Results: Through GO and KEGG analysis, we found that cAMP signaling pathway, estrogen signaling pathway, calcium signaling pathway was related with coronary heart disease. Using network-based systems biology, we predicted that 10 active ingredients in Cinnamomi Ramulus have the treating effects with 78 potential targets. PIK3CG, MAPK8, BCL-2, BAX, PRKACA, CASP3, CALM1, CALM2, CALM3, NOS2, NOS3 were mainly involved in the treating effects of Cinnamomi Ramulus. Conclusion: Cinnamomi Ramulus may treat coronary heart disease through cAMP signaling pathway, estrogen signaling pathway, calcium signaling pathway. PIK3CG, MAPK8, BCL-2, BAX, PRKACA, CASP3, CALM1, CALM2, CALM3, NOS2, NOS3 were supposed to be considerable targets for treating coronary heart disease.
Authors and Affiliations
Shi-Quan Chang, Yi Lin, Di Zhang, Jian-Xin Sun, Bing Yang, Guo-Ping Zhao
Keywords
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- EP ID EP696226
- DOI 10.12032/TMRIM202105011
- Views 73
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