Mechanisms of Diabetes-Induced Liver Damage The role of oxidative stress and inflammation
Journal Title: Sultan Qaboos University Medical Journal - Year 2016, Vol 16, Issue 2
Abstract
Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. Tis metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to nonalcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, fnally, hepatocellular carcinomas. Te underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Signifcant involvement of pro-inflammatory cytokines— including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α—exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. Tis review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.
Authors and Affiliations
Jamaludin Mohamed| Department of Biomedical Sciences, Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Nazratun Nafzah A. H. | Department of Biomedical Sciences, Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Zariyantey A. H. | Department of Biomedical Sciences, Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Budin S. B. | Department of Biomedical Sciences, Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
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