Mechanisms of Host Resistance Against HIV Infection and Progression to AIDS
Journal Title: Sultan Qaboos University Medical Journal - Year 2007, Vol 7, Issue 2
Abstract
Since the discovery in the early eighties of the Human Immunodeficiency Virus (HIV) that causes acquired immunodeficiency syndrome (AIDS), there have been reports of people who were completely resistant to infection with HIV and others who progressed at slower rates to AIDS. Te present article summarises the mechanisms involved in resistance against HIV infection and progression to AIDS. Te paper will specifically focus on the role of immunological mechanisms, genetics, ethnicity and cultural practices such as male circumcision in mitigating infection. Te current understanding on host natural resistance against HIV infection and progression to AIDS would potentially contribute to better prevention strategies, delayed onset of AIDS in people living with HIV, the identification of more efficient types of therapy for AIDS patients and, possibly, appropriate vaccines against HIV/AIDS. Tis area of research has important implications for patient care through controlling factors that contribute to AIDS progression.
Authors and Affiliations
Ali A Al-Jabri| Department of Microbiology & Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, PC 123, Al-Khod, Muscat, Sultanate of Oman
Keywords
Related Articles
- EP ID EP13713
- DOI -
- Views 319
- Downloads 17
Arabic Translation, Validation and Cultural Adaptation of the 7-Item Hamilton Depression Rating Scale in Two Community Samples.
Objectives: Depression is a common mental disorder, the severity of which is frequently assessed via interview-based clinical scales such as the 7-item Hamilton Depression Rating Scale (HAMD-7). The current study aimed t...
Avoidance of Laryngeal Injuries during Gastric Intubation
Gastric intubation is a common and simple procedure that is often performed on patients who are sedated or anaesthetised. If the gastric tube (GT) is inserted blindly while the patient is unconscious, this procedure ma...
Analysis of Tobacco-Specifc Nitrosamines in the Common Smokeless Tobacco Afzal in Oman
Objectives: Tere is a lack of awareness regarding the carcinogenicity of Afzal, an illegal smokeless tobacco product (STP) widely used among the Omani youth. Previous research has shown that certain types of tobacco-sp...
Imbalances in T Cell-Related Transcription Factors Among Patients with Hashimoto’s Thyroiditis
Objectives: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto’s thyroiditis (HT). Differentiation of effector T helper (T) 1, T2, T17 and regu...
The Epidemiology of Acute Coronary Syndrome in Oman Results from the Oman-RACE study
Objectives: This study aimed to evaluate the epidemiology and coronary risk factors of acute coronary syndrome (ACS) in Oman. Methods: Data were collected through a prospective, multinational, multicentre survey of con...