Mechanisms of Immune Dysregulation Induced by Pesticide Exposure and their Implications for Cancer: A Systematic Review
Journal Title: Advances in Clinical Toxicology - Year 2024, Vol 9, Issue 2
Abstract
The inappropriate use of pesticides contaminates natural resources and has consequences for human health. Evidence of immune dysregulation caused by pesticides has been presented, but studies linking exposure to these substances with immune dysregulation and its relationship to cancer are scarce. This study systematically reviews the published literature that addresses the topic of immune dysregulation and cancer and its relationship to pesticide exposure. Studies developed in vitro cell culture and in vivo experimental animals and human exposure data were included. The results show that pesticide exposure has a relevant impact on immune dysfunction, negatively affecting immune system cells and cytokine production in innate and adaptive responses. The main consequences reported were suppression of the Th1 response, induction of the Th2 response, cellular balance dysregulation, and cytokine production changes. All reported events are related to the occurrence of immunosuppression. This dysregulation is paramount for cancer progression and may lead to a worse prognosis in chronically exposed populations. These findings also point to the need for further studies, primarily focused on human exposure.
Authors and Affiliations
dos Santos SBG , Sandri G , de Oliveira KCS , Rossi MG , da Silva DFS , Nunes AT , de Jesus LV , Corona CF , Lima FAA , de Carvalho KAR , Dalmolin C , Panis C and Benvegnu DM
Advances in Clinical Toxicology depend on Ecotechnology
The oldest enriched habitat of the Banka-Siphon-Dam (BSD) of Banka River (BR) attached to Eden Canal (EC) of Damodar River (DR), Kanchannagar, Burdwan, West Bengal India, covering a 3-5 sq km area with different flora- a...
Post treatment of Water for Human Consumption for Removal of Toxic Compounds - Mini Review
The treatment of water for human consumption uses chemical /physical/biological processes to guarantee the potability and to avoid contaminations due to toxic compounds. The treatment of drinking water employs the follo...
Impact and Correlation of Air Quality and Climate Variables with Covid-19 Morbidity and Mortality in Dhaka, Bangladesh
The COVID-19 pandemic unexpectedly stopped the steady life and enhanced environmental quality. To apprehend the transmission of COVID-19 and the improvement of air quality, we have studied air quality indicators (PM2.5,...
The Toxicological Studies of Securidaca longepedunculata on the Heart, Liver, Kidney and Lungs of Rats
Securidaca lonpedunculata is a savannah plant widely distributed in Africa. The plant has a reputation of broad spectrum of medicinal, pharmacological and therapeutic properties, it is reported that almost all parts of...
Carbon Nanotubes-Doxorubicin Conjugates Molecular Dynamics and Bio-inspired Approaches for Clinical Toxicology
Doxorubicin as a therapeutic drug is used in several human pathologies related to cancer. It has however some side effects that needs to be understood and controlled. This article discusses some applications using singl...