MECHANOBIOLOGY IN STRUCTURAL LUNG CELLS AND THE IMPORTANCE OF IT’S CHANGES IN ASTHMA
Journal Title: Pulmonologija ir alergologija - Year 2017, Vol 1, Issue 1
Abstract
Mechanobiology is an emerging field of science at the interface of biology and engineering that focuses on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell differentiation, physiology and disease. A major challenge in the field is understanding mechanotransduction – the molecular mechanisms by which cells sense and respond to mechanical signals. While medicine has typically looked for the genetic and biochemical basis of disease, advances in mechanobiology suggest that changes in cell mechanics, extracellular matrix structure, or mechanotransduction may contribute to the development of many diseases, including atherosclerosis, fibrosis, asthma, osteoporosis, heart failure and cancer. Airway remodeling – irreversible airway structural changes associated with poorer asthma control and more serious disease course. The article reviews the basic structural cells participating in the pathogenesis of asthma, their mechanobiological changes and their influence on the clinical disease expression.
Authors and Affiliations
Virginija Kalinauskaitė-Žukauskė
Keywords
Related Articles
- EP ID EP266202
- DOI -
- Views 142
- Downloads 0
NAUJAI DIAGNOZUOTŲ LĖTINĖS OBSTRUKCINĖS PLAUČIŲ LIGOS ATVEJŲ TIESIOGINIAI MEDICININIAI KAŠTAI LIETUVOJE
Background. Chronic obstructive pulmonary disease (COPD) is an under-diagnosed, life-threatening lung disease, which is mainly caused by active smoking, and provokes significant financial burden for the health care secto...
LITHUANIAN RECOMMENDATIONS FOR DIAGNOSIS AND MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA
These recommendations establish clinical practice guidelines for the diagnosis and treatment of adult and children obstructive sleep apnea.
Lithuanian guidelines on evaluation and treatment of severe asthma in adults, 2017.
Lithuanian guidelines on evaluation and treatment of severe asthma in adults, 2017.
ADVERSE REACTIONS TO THE MAIN ANTITUBERCULOUS AGENTS
Despite the fact, that the first line antituberculous agents, created a few decades ago, are efficient and able to cure tuberculosis, their side effects that might manifest may vary from the clinically in...
EOSINOPHILS VIABILITY INCREASES AFTER THEIR INTERACTION WITH AIRWAY SMOOTH MUSCLE CELLS IN ASTHMA
Background. Viability of peripheral blood eosinophils are significantly lower than airway eosinophils. It may be assumed that direct contact between eosinophils and pulmonary structural cells increase eosinophils surviva...