Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2016, Vol 9, Issue 12
Abstract
Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and PubMed.
Authors and Affiliations
María Adelina Jimenez-Arellanes
Keywords
Related Articles
- EP ID EP279753
- DOI 10.1016/j.apjtm.2016.10.010
- Views 91
- Downloads 0
Recent research advances on Chromobacterium violaceum
Chromobacterium violaceum is a gram-negative bacterium, which has been used widely in microbiology labs involved in quorum sensing (QS) research. Among the QS-regulated traits of this bacterium, violacein production has...
The role of heme-oxygenase-1 in pathogenesis of cerebral malaria in the co-culture model of human brain microvascular endothelial cell and ITG Plasmodium falciparum-infected red blood cells
Objective: To investigate the role of human host heme-oxygenase-1 (HO-1) in pathogenesis of cerebral malaria in the in vitro model. Methods: The effect of human host HO-1 [human brain microvascular endothelial cell (HBME...
Domestic reptiles as source of zoonotic bacteria: A mini review
Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most well-known agent, whereas there are very scant...
Antidiabetic effects of galactomannans from Adenanthera pavonina L. in streptozotocin-induced diabetic mice
Objective: To evaluate the antidiabetic effect of galactomannans extracted from Adenanthera pavonina’s L. seeds (GAP) in streptozotocin (STZ) induced diabetic mice. Methods: The preliminary galactomannan yield from Adena...
Effects of aqueous extract of Notobasis syriaca on lipopolysaccharideinduced inflammation in rats
Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kg•d)] for thre...