Medication-induced inhibition of the activity of sensing quorum of Pseudomonas aeruginosa bacteria
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 4
Abstract
The scientific review deals with the modern concepts of the quorum sensing systems LasI/R, RhlI/R, PqsABCDH/R and IQS of Pseudomonas aeruginosa bacteria, the functioning of which causes their survival under the most unfavorable and bactericidal conditions. For writing the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka, RISC. High antibiotic resistance of Pseudomonas aeruginosa bacteria as causative agents for nosocomial infectious diseases is due to the ability to create a biofilm. The mechanisms of biofilm formation by Pseudomonas aeruginosa bacteria, which are represented by the quorum sensing system LasI/R, RhlI/R, PqsABCDH/R and IQS, are described. The data of scientific studies that reveal the role of quorum sensing-dependent virulence factors of the bacteria Pseudomonas aeruginosa in the pathogenesis of the infectious process are presented. The hierarchical unified organization of the quorum sensing of Pseudomonas aeruginosa bacteria in the formation of a biofilm was demonstrated. The formation of biofilm by Pseudomonas aeruginosa bacteria predetermines the lack of effectiveness of antibiotic therapy and the risk of developing a chronic process. Attention is focused on the possibilities of drug suppression of quorum sensing-associated factors of bacterial virulence and biofilm formation when using any molecular component of the quorum system of sensing bacteria Pseudomonas aeruginosa as a target. The characteristics of some compounds that inhibit the sensory system of Pseudomonas aeruginosa bacteria are given, and it is likely that they will be able to develop medicines for use in medical practice for the treatment of infections caused by Pseudomonas aeruginosa bacteria.
Authors and Affiliations
A. E. Abaturov, T. A. Kryuchko
Keywords
Related Articles
- EP ID EP613571
- DOI 10.22141/2224-0551.14.4.2019.174044
- Views 86
- Downloads 0
Criteria for the progression of steatohepatosis in obese adolescents with signs of metabolic syndrome
Background. To date, obesity in adolescents is a serious problem, which is caused by the prevalence of this pathology, especially in developed countries, and the possible consequences in the future, in particular, metabo...
Features of Motor and Secretory Disorders in Gastroesophageal Reflux Disease in Young Patients with Concomitant Obesity
The Objective of the Study. To identify the features of the motor and secretory disorders in gastroesophageal reflux disease, depending on the presence of concomitant obesity in young people. Materials and Results of the...
Application of Topical Preparations with Combined Effect in the Treatment of Inflammatory Diseases of the Oral Cavity and Pharynx
Acute infectious and inflammatory diseases of the oral cavity and pharynx are common in children and adults. The paper presents the possibilities of managing inflammatory process and pain syndrome, which develop in these...
Results of studying the sensitivity of Ukrainian version of Haemo-QoL Questionnaire
Background. To determine the sensitivity to changes of the Ukrainian version of questionnaire for assessing the health-related quality of life in children with hemophilia (Haemo-QoL) was the purpose or our work. Material...
Place of nasal decongestants in the treatment of acute infectious rhinosinusitis in children
Acute infectious rhinosinusitis is the most common clinical form of respiratory pathology in childhood. Despite the fact that in 90 % of cases the main etiological factor leading to the development of rhinosinusitis is v...