Medication-induced inhibition of the activity of sensing quorum of Pseudomonas aeruginosa bacteria
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 4
Abstract
The scientific review deals with the modern concepts of the quorum sensing systems LasI/R, RhlI/R, PqsABCDH/R and IQS of Pseudomonas aeruginosa bacteria, the functioning of which causes their survival under the most unfavorable and bactericidal conditions. For writing the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka, RISC. High antibiotic resistance of Pseudomonas aeruginosa bacteria as causative agents for nosocomial infectious diseases is due to the ability to create a biofilm. The mechanisms of biofilm formation by Pseudomonas aeruginosa bacteria, which are represented by the quorum sensing system LasI/R, RhlI/R, PqsABCDH/R and IQS, are described. The data of scientific studies that reveal the role of quorum sensing-dependent virulence factors of the bacteria Pseudomonas aeruginosa in the pathogenesis of the infectious process are presented. The hierarchical unified organization of the quorum sensing of Pseudomonas aeruginosa bacteria in the formation of a biofilm was demonstrated. The formation of biofilm by Pseudomonas aeruginosa bacteria predetermines the lack of effectiveness of antibiotic therapy and the risk of developing a chronic process. Attention is focused on the possibilities of drug suppression of quorum sensing-associated factors of bacterial virulence and biofilm formation when using any molecular component of the quorum system of sensing bacteria Pseudomonas aeruginosa as a target. The characteristics of some compounds that inhibit the sensory system of Pseudomonas aeruginosa bacteria are given, and it is likely that they will be able to develop medicines for use in medical practice for the treatment of infections caused by Pseudomonas aeruginosa bacteria.
Authors and Affiliations
A. E. Abaturov, T. A. Kryuchko
Keywords
Related Articles
- EP ID EP613571
- DOI 10.22141/2224-0551.14.4.2019.174044
- Views 97
- Downloads 0
Gilbert’s syndrome: clinical features, diagnostics, differential diagnosis and treatment (part 2)
We searched for published and unpublished research using PubMed as the search engine by the keywords: “Gilbert’s syndrome”, “clinical manifestation”, “diagnosis”, “treatment”, taking into consideration studies conducted...
The Role of Long-Chain Polyunsaturated Fatty Acids in the Nutrition of Infants
Long-chain polyunsaturated fatty acids (LCPSFA) are the main functional fats of mother’s milk. The predominant and functionally most important LCPSFA are arachidonic acid (AA) and docosahexanoic acid (DHA). In addition t...
The effectiveness of ozone therapy as a non-drug method for treatment of initial caries of permanent teeth in children
Background. It is proved that the use of ozone will contribute to the growth of caries dental resistance, but the question about the adequacy of this method for the complete restoration of the already partly demineralize...
The peculiarities of combined pathology of the upper gastrointestinal tract with allergic dermatoses in children
Background. The recent studies indicate that one of the causes of allergic dermatoses (AD) in children and adults is pathology of the gastrointestinal tract. However, many problems of the emergence of these combinations...
Depression and Associated Suicidal Behaviour in Children and Adolescents: Current Views and the Problem State Part 2
There has been performed the analytical analysis of the world literature dedicated to the epidemiology, etiology, current approaches to the pathogenesis, clinical picture and diagnosis criteria for the depressive disorde...