Medication related osteonecrosis of the jaws. Literature review
Journal Title: ΑΡΧΕΙΑ ΕΛΛΗΝΙΚΗΣ ΣΤΟΜΑΤΙΚΗΣ ΚΑΙ ΓΝΑΘΟΠΡΟΣΩΠΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ - Year 2018, Vol 19, Issue 1
Abstract
Medication related osteonecrosis of the jaws (MRONJ) is a clinical entity that may develop in patients receiving antiresorprtive (bisphosphonates and denosumab) or antiangiogenic agents. The main objective of this article is to review the pertinent literature regarding medications that may cause MRONJ, its pathophysiology, etiologic factors, epidemiological, radiological and clinicopathological features as well as therapeutic approaches. It is critical for the dentist, to inform the patients at risk for developing MRONJ, to be able to timely diagnose the disease in order to contribute to its prevention and proper management. Diagnosis is based on the patient’s medical history and clinical findings. Medical history should be thoroughly investigated with emphasis on medications related to MRONJ. Maintenance of an excellent oral hygiene and intensive dental care before and during treatment, are preventive measures aiming to reduce the risk of MRONJ. Treatment protocol is related to the stage of the disease and ranges from conservative management (topical antimicrobial agents in combination with systemic antibiotics), to surgical interventions performed by specialized surgeons. Histopathological examination of the surgically removed specimens is mandatory in order to exclude other pathological conditions or metastatic disease.
Authors and Affiliations
Paris TAMIOLAKIS, Grigorios THERMOS, Anastasios CHAROULIS, Evanthia CHRYSOMALI, Alexandra SKLAVOUNOU-ANDRIKOPOULOU
Keywords
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