Medication related osteonecrosis of the jaws. Literature review
Journal Title: ΑΡΧΕΙΑ ΕΛΛΗΝΙΚΗΣ ΣΤΟΜΑΤΙΚΗΣ ΚΑΙ ΓΝΑΘΟΠΡΟΣΩΠΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ - Year 2018, Vol 19, Issue 1
Abstract
Medication related osteonecrosis of the jaws (MRONJ) is a clinical entity that may develop in patients receiving antiresorprtive (bisphosphonates and denosumab) or antiangiogenic agents. The main objective of this article is to review the pertinent literature regarding medications that may cause MRONJ, its pathophysiology, etiologic factors, epidemiological, radiological and clinicopathological features as well as therapeutic approaches. It is critical for the dentist, to inform the patients at risk for developing MRONJ, to be able to timely diagnose the disease in order to contribute to its prevention and proper management. Diagnosis is based on the patient’s medical history and clinical findings. Medical history should be thoroughly investigated with emphasis on medications related to MRONJ. Maintenance of an excellent oral hygiene and intensive dental care before and during treatment, are preventive measures aiming to reduce the risk of MRONJ. Treatment protocol is related to the stage of the disease and ranges from conservative management (topical antimicrobial agents in combination with systemic antibiotics), to surgical interventions performed by specialized surgeons. Histopathological examination of the surgically removed specimens is mandatory in order to exclude other pathological conditions or metastatic disease.
Authors and Affiliations
Paris TAMIOLAKIS, Grigorios THERMOS, Anastasios CHAROULIS, Evanthia CHRYSOMALI, Alexandra SKLAVOUNOU-ANDRIKOPOULOU
Keywords
Related Articles
- EP ID EP509316
- DOI -
- Views 27
- Downloads 0
Τρισμός οφειλόμενος σε κεφαλικό τέτανο Παρουσίαση περίπτωσης
Ως τρισμός ορίζεται η αδυναμία διάνοιξης του στόματος. Στη διαφορική διάγνωση περιλαμβάνονται λοιμώξεις, τραύμα, νεοπλάσματα, παθήσεις της κροταφογναθικής διάρθρωσης κ.ά. Ο κεφαλικός τέτανος αποτελεί μια σπάνια μορφή τετ...
Μονήρες νευροΐνωμα γλώσσας Παρουσίαση σπάνιας περίπτωσης
Το νευροΐνωμα είναι ένας σπάνιος, μη οδοντογενής όγκος της στοματικής κοιλότητας, αποτελούμενος από ένα ποικίλο μίγμα κυττάρων Schwann, περινευρικών κυττάρων και ινοβλαστών. Κλινικά εμφανίζεται ως βραδείας εξέλιξης έμμισ...
Βασικοκυτταρικό αδένωμα παρωτίδας. Παρουσίαση 3 περιπτώσεων
Παρουσιάζονται 3 περιπτώσεις βασικοκυτταρικού αδενώματος (ΒΚΑ) που αντιμετωπίστηκαν στην κλινική μας. Αιτία προσέλευσης των ασθενών ήταν οπισθογναθιαία διόγκωση, η οποία εμφάνιζε τυπικά κλινικά χαρακτηριστικά καλοήθους π...
Pleomorphic adenoma of minor salivary gland. Report of a case and a brief review of the literature
SUMMARY: A case of a pleomorphic adenoma of minor salivary gland, located at the left buccal mucosa, is being described, as well as the treatment of choice. The histologic origin of the tumor along with a brief review of...
Squamous odontogenic tumor-like proliferations: Report of 6 cases and review of the literature
Squamous odontogenic tumor-like proliferations (SOTLPs) are epithelial nests located within the wall of odontogenic cysts and are histologically similar to the squamous odontogenic tumor. Aim: To present the clinical and...