Meldonium and neuroprotection. Theory, experiment and clinical practice
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 2
Abstract
In this review the possibilities of correction of brain metabolism in cases of acute cerebral ischemia (ACI) under using meldonium were considered. The biochemical specificity of this remedy in Krebs cycle, influence on cerebral glycolysis, by activating the stress-limiting system, lactate-glutamate and glycogen mechanisms of the biochemical shunt were discussed. There were described effects of meldonium on cerebral processes that can be conditionally separated into carnitine-dependent and carnitine-independent. Results of experimental research of meldonium proved certain metabolic influence on NMDA receptor system. The analysis of the results of experimental and clinical studies makes it possible to consider that any neuroprotective pharmacological remedies have comparatively low efficacy in cases of acute cerebral ischemia. Meldonium effects do not differ from others similar neuroprotective remedies in such cases. In experimental works meldonium can improve metabolism in central nervous system (CNS) and would be considered as a pharmacological remedy that creates conditions for optimizing and economizing metabolism of the CNS. Meldonium in experimental conditions (predominantly in mice) can help to optimize metabolism of glucose in the CNS, especially aerobic glycolysis that creates opportunities to form economizing way of the basic metabolism. In target usage of the drug in the experiment a "smooth exit" from the ischemic state and decrease of the negative effects of oxidative stress is possible. Possible areas and clinicaly unproved efficiency of the drug in ACI should be considered while planning therapy of ACI and at the stages of rehabilitation.
Authors and Affiliations
V. P. Muslin, O. V. Pohorielov
Keywords
Related Articles
- EP ID EP305124
- DOI 10.26641/2307-0404.2018.2.133951
- Views 87
- Downloads 0
Prediction of course and progression of nonalcoholic fatty liver disease in patients with obesity and pathology of the biliary tract with the help of mathematical modeling
Determination of the most important functional parameters of the liver, lipid peroxidation (LPO) and antioxidant protection (AOP) markers of endogenous intoxication and indicators of connective-tissue metabolism in patie...
Сatamnesis of organic hallucinosis case at pituitary macroadenoma
The article describes a one-year follow-up study of the clinical case of organic hallucinosis that we have described in the previous article in the patient with pituitary macroadenoma. At primary admission to the hospita...
Вплив процесів протеолізу на розвиток і прогресування серцевої недостатності ішемічного генезу залежно від наявності реваскуляризації
Проведено исследование и сравнительная оценка активности матриксных металлопротеиназ ММП-9 и ММП-2 у 187 больных с хронической ишемической болезнью сердца и всеми формами острого коронарного синдрома, со средним возрасто...
Methodological approaches to estimation of teenagers' health
On the basis of International classification of functioning, limitations of vital activity and health, model of estimation of teenagers' health considering these changes from positions of functioning of the organism and...
Features of the treatment of elderly patients with coronary heart disease at the stages of 1990, 2010 and 2017 examinations
The purpose of the work is to determine the characteristics of prescription, adherence to treatment and the effect of certain classes of drugs used for the treatment of cardiovascular diseases on the life expectancy of e...