Membrane Stabilizing Activity and Protein Denaturation: A Possible Mechanism of Action for the Anti-Inflammatory Activity of Phyllanthus amarus
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2012, Vol 1, Issue 1
Abstract
Background: Previous studies confirm the anti-inflammatory potential of Phyllanthus amarus herb. Aim and objective: Primary aim of the present study was to investigate the possible anti inflammatory mechanism of Phyllanthus amarus extract using in-vitro models. Material & method: Aqueous extract of Phyllanthus amarus was evaluated in vitro models for haemolysis of erythrocytes and % inhibition in heat induced protein denaturation at three doses of 50 mg/kg, 100 mg/kg & 200 mg/kg. Results: The aqueous extract of Phyllanthus amarus significantly inhibited the haemolysis of erythrocytes and heat induced protein denaturation as compared to control. Conclusion: It can be postulated from the observed results that the anti-inflammatory activity of Phyllanthus amarus could be due to its membrane stabilizing action and inhibition of protein denaturation.
Authors and Affiliations
Atul R. Chopade, Prakash M. Somade, Fahim J. Sayyad
Keywords
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