Memory enhancing activity of Momordica charantia by scopolamine induced amnesia in rats
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2017, Vol 2, Issue 1
Abstract
The present study was undertaken to investigate the effect of Momordica charantia on cognitive functions, total cholesterol levels and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The paste of Momordica charantia was administered orally at three doses (150, 300 and 600 mg/kg) for 7 and 14 consecutive days to the respective groups of rats. Piracetam (200 mg/kg) was used as a standard nootropic agent. Learning and memory parameters were evaluated using elevated plus maze (EPM), passive avoidance and motor activity paradigms. Brain ChE activity and serum biochemical parameters like total cholesterol, total triglycerides and glucose were evaluated. It was observed that Momordica charantia at the above-mentioned doses after 7 and 14 days of administration in the respective groups significantly reversed scopolamine (1 mg/kg i.p.)-induced amnesia, as evidenced by a decrease in the transfer latency in the EPM task and step-down latency in the passive avoidance task. Momordica charantia reduced the brain ChE activity in rats. Momordica charantia also exhibited a remarkable cholesterol and triglyceride lowering property and slight increase in glucose levels in the present study.
Authors and Affiliations
Ankur Joshi, Priyanka Soni, Sapna Malviya, Anil Kharia
Keywords
Related Articles
- EP ID EP318762
- DOI -
- Views 104
- Downloads 0
Clinical comparison of Annabedi Chendhuram (siddha system of medicine) and elemental iron in the treatment of iron deficiency anaemia
Introduction Healthy human body needs iron for multiple process during development Several diseases are associated with iron deficiency and increased demands also may lead to iron deficiency Many diseases have been addre...
Importance of medication adherence and factors affecting it
Nonadherence leads to considerable morbidity mortality and avoidable health care costs adherence averages to only 50 in patients suffering from chronic medical illness Often adherence and compliance are used interchange...
A non-pharmacological diagnostic approach to study correlation between anthropometric indices and lipid profile in adult females-A review
The prevalence ofdyslipidaemia has increased manifold in the industrialized developed and the developing countries to an extent that it is becoming an escalating epidemic Obesity an important risk factor of dyslipidaemia...
Biofilm formation and extended spectrum beta-lactamase production in Klebsiella pneumoniae isolates from respiratory samples in a tertiary care hospital
Nosocomial and community acquired infections are being caused by Klebsiella pneumoniae K pneumoniae worldwide K pneumoniae among gram negative organisms is an important bacterium responsible for site specific infection w...
Pharmacokinetics interaction of calcium on the treatment of sputum positive pulmonary tuberculosis patients
Introduction Tuberculosis TB in children is a neglected aspect of the TB epidemic despite it constituting 20 or more of all TB cases in many countries with high TB incidence Tuberculosis constitutes a serious global heal...