Meta-Analysis of Ado-Trastuzumab Emtansine in Patients with HER2- Positive Advanced Metastatic Breast Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
This study identifies and reviews randomized evidence to determine the effectiveness and safety of AdoTrastuzumab Emtansine in patients with advanced metastatic breast cancer. Cochrane Breast Cancer Group specialized register; Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL and WHO International Clinical Registry platform were searched using the appropriate search strategy. Either recurrent or newly diagnosed women with Metastatic Breast Cancer were included. Four randomized controlled trials with 1,350 patients estimated overall survival as 64.7% in TDM1 group versus 51.8% in non TDM1 group. EMILIA study reported improved progression free survival (PFS) by 5.8 months, Overall Response Rate (ORR) as 43.6% in TDM1 group vs. 30.8% control group and low adverse events by 16.2%. Hurvitz study reported PFS 5 months longer in T-DM1 group than in control group with stratified HR of 0.59;(95% CI, 0.36 to 0.97), ORR as 64.2% (TDM 1 group) vs. 58% in control group, low adverse events by 45.2%. Single arm phase II study BURRIS & KROP reported PFS as 4.6 and 6.9 months respectively, ORR 25.9% and 34.5% respectively, and adverse events as 15.2% and 55.4% respectively. Consistent favorable outcomes with the Ado-Trastuzumab Emtansine indicate its considerable efficacy and safety in the treatment of advanced metastatic breast cancer and promising drug in combating mortality with breast cancer.
Authors and Affiliations
Dr Rajat Rana
Keywords
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