Meta-Analysis of Ado-Trastuzumab Emtansine in Patients with HER2- Positive Advanced Metastatic Breast Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
This study identifies and reviews randomized evidence to determine the effectiveness and safety of AdoTrastuzumab Emtansine in patients with advanced metastatic breast cancer. Cochrane Breast Cancer Group specialized register; Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL and WHO International Clinical Registry platform were searched using the appropriate search strategy. Either recurrent or newly diagnosed women with Metastatic Breast Cancer were included. Four randomized controlled trials with 1,350 patients estimated overall survival as 64.7% in TDM1 group versus 51.8% in non TDM1 group. EMILIA study reported improved progression free survival (PFS) by 5.8 months, Overall Response Rate (ORR) as 43.6% in TDM1 group vs. 30.8% control group and low adverse events by 16.2%. Hurvitz study reported PFS 5 months longer in T-DM1 group than in control group with stratified HR of 0.59;(95% CI, 0.36 to 0.97), ORR as 64.2% (TDM 1 group) vs. 58% in control group, low adverse events by 45.2%. Single arm phase II study BURRIS & KROP reported PFS as 4.6 and 6.9 months respectively, ORR 25.9% and 34.5% respectively, and adverse events as 15.2% and 55.4% respectively. Consistent favorable outcomes with the Ado-Trastuzumab Emtansine indicate its considerable efficacy and safety in the treatment of advanced metastatic breast cancer and promising drug in combating mortality with breast cancer.
Authors and Affiliations
Dr Rajat Rana
Keywords
Related Articles
- EP ID EP205926
- DOI -
- Views 76
- Downloads 0
Hypolipidemic activity of Trichopus zeylanicus leaf extract against alloxan induced diabetes mellitus in male albino rats.
Trichopus zeylanicus is a plant with adaptogenic properties. This experiment with three groups of rats was designed to evaluate the beneficial properties of T. zeylanicus consumption on LPO, AO, blood glucose regulation...
Mannitol Vs Hypertonic Saline in the Treatment of Increased Intracranial Pressure in Traumatic Brain Injury Patients
Medical management of increased intracranial pressure should include sedation, drainage of cerebrospinal fluid, and osmotherapy with either mannitol or hypertonic saline. The aim of this study is to compare the effects o...
Comparison of Various Modes of Fixation in Fracture Shaft of Both Bones Forearm
The Study compares the outcomes of fracture shaft of both bones forearm treated by either intra medullary nailing or dynamic compression plating. Objectives: To compare the functional outcome of 2 different conventional...
Obstetric Outcome Following Vesicular Mole Evacuation in a Tertiary Care Centre
Background: Gestational Trophoblastic Diseases (GTD) are a group of diseases in which the basic disorder lies in the abnormal development and growth of trophoblast. The success story of the GTD is the curability by chemo...
Adjusted Blood Cell Glucose (ABC-G) In Diabetics and Non Diabetics
Aims and objectives: The aim of our study was estimation and comparison of ABC-G in Diabetic & Non Diabetic patients Design: Comparative study. Material and Methods: Total numbers of 250 coded blood samples were processe...