Meta-Analysis of Liver Cirrhosis and The Risk of Fracture
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 8
Abstract
<strong>Background:</strong> Cirrhosis is the irreversible fibrosis of liver, it continues to be a common cause of morbidity and mortality. It is accompanied by inflammation and malnutrition and thus can have a negative effects on bone metabolism and promote fractures accordingly. <strong>Aim of the study: </strong>to evaluate the risk of fractures among patients with cirrhosis. <strong>Methods:</strong> A systematic review of the scientific literature following PRISMA/STROBE guidelines, Medline Cochrane Library and Embase abstracts were retrieved using an algorithm comprising relevant MeSH terms from 1980 to 2017. Publications on the association of cirrhosis/bone fracture were abstracted independently by the authors and included in both gender and gender-specific meta-analyses, following recalculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. <strong>Results:</strong> 8 studies met the inclusion criteria enrolling 988 patients (286 of which are diagnosed with alcoholic liver disease (ALD). Overall, ALD demonstrated a relative risk (RR) of 1.825, 95%CI: 1.370-2.28, <strong><em>P</em></strong> < 0.001 for the development of bone fractures. Bone mineral density (BMD) was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD. Sensitivity analyses showed consistent results. <strong>Conclusion:</strong> in accordance to the present meta-analysis, there is a significant correlation between bone fractures and ALD independent of BMD.
Authors and Affiliations
Eman Helal
Keywords
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