Meta-analysis of the association of T102C polymorphism in HTR2A gene of 5-HT2A receptor and schizophrenia
Journal Title: Вісник Харківського національного університету імені В.Н.Каразіна. Серія "Біологія" - Year 2016, Vol 27, Issue
Abstract
HTR2A gene codes the serotonin receptor 5-HT2A and is located on the long arm of chromosome 13. A marked decrease in the density of these receptors in different areas of the cortex was observed in the brains of patients with schizophrenia. This meta-analysis confirmed the connection between schizophrenia and a marker on the long arm of chromosome 13 as a C-allelic form of T102C polymorphism of HTR2A gene. Previous studies have shown that this association is more prominent in European samples, while in East Asia it is absent. This study defines that the strongest association takes place in the Russian samples, where the value of the odds ratio for the C allele is: OR=2,1; 95% CI 1,5–2,9; for the genotype CC OR=3,9; 95% CI 2,1–7,4. In populations of other countries (Israel, Brazil, Finland, Canada) such association was not revealed. The fact that the association of T102C polymorphism with schizophrenia has been confirmed for the Russian population that is genetically close to Ukrainian, is an important precondition for such research in Ukraine to determine provocative allele to find the risk of schizophrenia, to carry out pharmacogenetic studies etc.
Authors and Affiliations
O. Bezuhla
Keywords
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