Meta-analysis of the clinical efficacy and safety of Urinary Kallidinogenase in the treatment of acute cerebral infarction
Journal Title: TMR Clinical Research - Year 2020, Vol 3, Issue 4
Abstract
Objective: To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction. Methods: PubMed, The Cochrane Library, Embase, CNKI, VIP, Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase 's treatment of acute cerebral infarction. The time limit was set up until September 2019. At the same time, the references and grey literature in the literature were manually screened. Two independent researchers were screened, evaluated and extracted according to inclusion and exclusion criteria. Meta-analysis was carried out by RevMan 5.3 software. Results: A total of 17 randomized controlled trials involving 2,066 patients, including 1,033 in the experimental group, and 1,033 in the control group. meta-analysis results showed that compared with the conventional treatment, Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction [OR = 3.26, 95%CI (2.56, 4.16), P < 0.00001]; the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group. Urinary Kallidinogenase group activity of daily living scale was better than the control group [OR = 21.33, 95%CI (6.64, 36.01), P = 0.004]; a total of 7 articles reported adverse reactions, including 19 cases in the trial group and 21 cases in the control group, the main adverse reactions were blood pressure drop, other symptoms were chest tightness, facial redness, dizziness fever, nausea and vomiting, arrhythmia, and no other serious adverse reactions. It can recover itself. Conclusion: the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction, and is safe. However, the quality of the study is limited.
Authors and Affiliations
Yuan Qin1, Qian Yi2, Hui-Hui Shi2, Ya-Lin Qi2*, Jing-Yue Hu2
Keywords
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- EP ID EP692784
- DOI 10.12032/TMRCR20200728016
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