Metabolic profile of patients with coronary artery disease and comorbid obesity
Journal Title: Медичні перспективи - Year 2018, Vol 23, Issue 1
Abstract
Cardiovascular diseases (CVD) are the leading cause of death worldwide. Most CVD can be prevented by modification of such risk factors as tobacco use, obesity and unhealthy diet, physical inactivity and harmful use of alcohol. Patients with CVD or who are at high cardiovascular risk due to the presence of risk factors such as dyslipidemia, hypertension, diabetes mellitus type 2, need early detection and management of these states. The article describes differences between metabolic profile of patients with obesity and coronary artery disease. The study included 58 patients. They were divided into 3 groups: 1st - patients with BMI <30 and CAD, 2nd - patients with BMI>30 and CAD, and 3rd - patients with BMI>30. 1st and 2nd group of patients were treated with atorvastatin in the dose of 40 mg for 2 years, 3rd - untreated. The results indicate that significant difference was faund in the lipid profile between groups of patients treated with atorvastatin in the dose of 40 mg . Transaminases and uric acid levels were different but within the reference range. The difference was found in serum glucose, insulin and HOMA-IR between participants of the 2-nd and other groups. We observed significant insulin resistance in the group of patients with coronary heart disease, obesity, treated with atorvastatin. So, administration of atorvastatin to the patients with IHD and obesity may negatively impact carbohydrate exchange and serve as a possible cause of diabetes melitus type 2 development.
Authors and Affiliations
T. Maksymets, A. F. Faynyk, E. Sklyarov
Keywords
Related Articles
- EP ID EP320063
- DOI 10.26641/2307-0404.2018.1(part2).126943
- Views 86
- Downloads 0
Features of the influence of subclinical hypothyroidism on the cardiovascular system
Dysfunction of the thyroid gland has serious consequences for the state of the cardiovascular system. In conditions of deficiency of thyroid hormones, the production of a number of cellular enzymes decreases, that leads...
Клинические особенности депрессивных расстройств у больных с онкопатологией головного мозга
Метою дослідження було вивчити психопатологічну структуру та клінічні особливості депресивних розладів у хворих на онкопатологію головного мозку. Поліморфні психічні порушення різного клінічного змісту і ступеня виражено...
Hygienic estimation of aqueous objects state in places of water use by population of Ukrainian Danube region
The literature data and results of monitoring of the aqueous objects of Ukrainian Danube region on sanitary-microbiological, physical and chemical and sanitary-chemical indicators testify to adverse changes of thei...
Features of interrelation of the structural state of brachiocephalic arteries in middle-aged and elderly patients with characteristics of the daily profile of blood pressure in patients with essential arterial hypertension stage II
The aim of our study was to evaluate the interrelation of the structural state of brachiocephalic arteries with the characteristics of the daily profile of blood pressure (BP) in middle-aged and elderly patients with ess...
Causes of cognitive impairments development and their manifestations in patients with arterial hypertension
The article considers risk factors for the development of cognitive disorders, the most powerful of which is age. The role of the cardiovascular system diseases in the formation of cognitive impairments, in particular, t...