Metabolic syndrome in patients with diabetes mellitus type 2 and its relation with retinal microvascular complication (diabetic retinopathy)
Journal Title: Scholars Academic Journal of Biosciences - Year 2015, Vol 3, Issue 8
Abstract
Abstract: To find out frequency of MS and its components in type 2 DM cases and to evaluate its relation with retinal microvascular complication (diabetic retinopathy, DR). In this study 300 cases of Type 2 DM were recruited. The grading of the severity of DR and diagnosis of CSME was done using ETDRS protocol. MS was defined using modified NCEP ATP III criteria. MS was found in 180/300 (60%) cases. Subjects with MS had statistically significant higher BMI, wider WC, higher TG and high frequency of HTN (p <0.05 for each). DR was found in 45% cases of MS and CSME was found in 21.70% cases. The MS was not significantly associated with DR or CSME in this study (p>0.05 for each). The frequency of DR among patients having >10 years duration of DM was higher (53/56, 94.62%) than patients with < 10 year duration of DM (84/244, 34.43%). But in patients of MS having DM duration <10 years, frequency of DR (49/146, 33.6%) was not different than patients without MS. Also in MS patients with DM duration >10 years, frequency of DR (32/34, 94.1%) was not different from patients without MS (p>0.05 for each). The independent risk factor for DR were glycated hemoglobin (OR 6.2019, 95% CI 3.7179-10.3456, p < 0.0001) and hypertriglyceridemia (OR 3.4983, 95% CI 1.9949-6.1344, p <0.0001). MS was highly frequent (60%) among DM cases. It was significantly associated with female gender, obesity, higher TG and HTN. The independent risk factors for DR were hypertriglyceridemia and glycosylated hemoglobin. Keywords: Metabolic Syndrome, Diabetes mellitus, Diabetic Retinopathy
Authors and Affiliations
Dr. Khushbu Jindal, Dr. Laxmi Kant Goyal, Dr. Kamlesh Khilnani
Keywords
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