Metformin and Bone Metabolism
Journal Title: Journal of Orthopaedic Science and Research - Year 2021, Vol 2, Issue 1
Abstract
Metformin is a member of biguanide antidiabetic drugs which has been widely used for treatment of Type 2 Diabetes Mellitus (T2DM) over 40 years. Bone is a highly dynamic tissue and its homeostasis mainly depends on the balance between bone resorption and bone formation through regulation of osteoblasts and osteoclasts. Recent studies showed that metformin has beneficial effects in maintaining bone metabolism [1,2]. Intriguingly, it has been reported that metformin has no effect on glucose levels in nondiabetic individuals [3,4]. These evidences suggested that metformin might be a considerable medication option for treatment of bone loss or prevention of fracture in patients with T2DM. However, its mechanism of action is becoming complicated and not fully understood according to recent emerged data. The aim of this review was to elaborate the potential signalling pathways of metformin on regulation of bone metabolism.
Authors and Affiliations
Jun Li
Keywords
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- EP ID EP698811
- DOI http://dx.doi.org/10.46889/JOSR.2021.2101
- Views 68
- Downloads 0
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